机构地区:[1]新疆维吾尔自治区人民医院高血压中心新疆维吾尔自治区高血压研究所,乌鲁木齐830001
出 处:《中华心血管病杂志》2012年第2期120-124,共5页Chinese Journal of Cardiology
基 金:新疆维吾尔自治区科技成果转化专项资金项目(201154126)
摘 要:目的 调查高血压人群的睡眠呼吸暂停低通气综合征( OSAHS)的患病情况及肥胖对其检出的影响.方法 对2009年4月1日至6月30日以高血压为主诉就诊于新疆维吾尔自治区人民医院高血压专科的住院患者,经病史询问存在睡眠时打鼾、白天嗜睡伴或不伴颈部粗短、下颌短小、舌肥大、无法解释的口舌发绀的疑似OSAHS患者,均行多导睡眠监测(PSG).定义阻塞性睡眠呼吸暂停低通气指数( AHI)≥5次/h且伴有临床症状诊断为OSAHS.结果 (1)住院高血压患者中OSAHS检出率为23.52%( 178/825);男性患者的OSAHS检出率为34.34%( 148/431),女性为11.68% (46/394).(2)以体质指数(BMI)为标准分组,正常组、超重组和肥胖组的OSAHS检出率分别为6.6% (12/183)、22.22% (78/351)和36.75%( 104/283),组间差异有统计学意义(x2=56.736,P<0.01);肥胖组的重度OSAHS的比例16.61% (47/283)高于体质量正常组和超重组的2.19% (4/183)和7.69% (27/351),差异有统计学意义(x2=29.219,P<0.01).(3)以腰围为标准分组,正常腰围组和中心性肥胖组的OSAHS检出率分别是7.83% (9/115)和26.29% (184/700),差异有显著统计学意义(x2=18.623,P<0.01);中心性肥胖患者的重度OSAHS占10.57%( 74/700),正常腰围者为2.61%(3/115),差异有显著统计学意义(x2=7.32,P<0.01).(4)性别分层后,女性患者中BMI高的患者,中重度OSAHS患者的检出率增高,差异有统计学意义(x2=5.846,P<0.05);在男性患者中BMI和腰围大者,中重度OSAHS的检出率高,差异均有显著统计学意义(P<0.01).结论 高血压人群中OSAHS的检出率较高,肥胖可能是影响OSAHS检出率的重要因素.Objective To investigate the impact of obesity on incidence of obstructive sleep apneahypopnea syndrome(OSAHS) in hospitalized hypertensive patients.Methods A total of 825 hospitalized hypertensive patients from April 1 to June 30 in 2009 in our hospital were included.Patients were asked to answer the questions concerning snoring,daytime sleepiness. Patients with loud snoring and daytime sleepiness,tubbiness neck,retrognathia,enlarged tongue,orolingual cyanosis were selected to undergo polysomnography monitoring for a whole night.OSAHS is defined by clinical symptoms and apnea-hypopnea index (AHI) not less than 5 per hour.Results (1) The detection rate of OSAHS in this cohort was 23.52% (178/825),34.34% ( 148/431 ) in males and 11.68% (46/394) in females respectively.(2) The detection rate was 6.6% (12/183) in normal weight subjects,22.22% (78/351) in overweight subjects and 36.75% (104/283) in obesity subjects ( x2 =56.736,P 〈0.01 ).The severe OSAHS rate in obesity group ( 16.61% ) was significantly higher than that in normal weight group (2.19% ) and overweight group (7.69%,x2 =29.219,P〈0.01). (3) The OSAHS rate was 7.83% (9/115) in normal waist circumference group and 26.29% (184/700) in centricity obesity group ( x2 =18.623,P 〈 0.01 ).The severe OSAHS rate was 2.61% (3/115) in normal waist circumference group and 10.57% (74/700) in centricity obesity (x2 =7.32,P 〈0.01 ).(4) The moderate to severe OSAHS rate increased in proportion with BMI increase in female patients ( x2 =5.846,P 〈 0.05) and increased in proportion with BMI and waist circumference increase in male patients ( P 〈 0.01 ).Conclusions The incidence of OSAHS in hypertensive patients is high.Obesity further increases the morbidity of OSAHS in hypertensive patients.
分 类 号:R766[医药卫生—耳鼻咽喉科]
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