纳米羟基磷灰石/聚磷酸钙纤维/聚乳酸骨组织工程复合支架的特性  

Fabrication and properties of nanometer hydroxyapatite/calcium polyphosphate/poly(L-lactic acid) composite scaffold for bone tissue engineering

作　　者：朱凌云[1] 王彦平[1] 石宗利[1] 张红梅[1] 

机构地区：[1]兰州交通大学机电工程学院材料系,甘肃省兰州市730070

出　　处：《中国组织工程研究与临床康复》2012年第3期431-433,共3页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：甘肃省自然科学基金资助项目(096RJZA085)~~

摘　　要：背景:近年来国内外在骨与软骨组织支架复合材料方面进行了广泛的研究,取得了积极的成果,但仍存在许多问题。目的:观察纳米羟基磷灰石/聚磷酸钙纤维/聚乳酸(HAP/CPP/PLLA)骨组织工程支架复合材料的特性。方法:采用溶媒浇铸、粒子滤取技术与气体发泡相结合的方法制备出纳米HAP/CPP/PLLA骨组织工程支架复合材料,测试该支架复合材料的物理力学性能,并用扫描电子显微镜对其微观结构进行观察。结果与结论:结果表明,纳米HAP/CPP/PLLA支架复合材料具有三维、连通、微孔网状结构,并具有较高的孔隙率和较好的压缩模量,是理想的骨组织工程支架材料。BACKGROUND：Studies have achieved great progresses in compound materials for bone and cartilage tissue scaffolds.However,there are still some problems.OBJECTIVE：To observe the fabrication and properties of nanometer hydroxyapatite/calcium polyphosphate/poly（L-lactic acid）（nanometer HAP/CPP/PLLA） composite scaffold for bone tissue engineering.METHODS：Nanometer HAP/CPP/PLLA composite scaffold was prepared by solvent casting,particulate leaching combined with gas foaming.The properties of physical mechanics were tested.RESULTS AND CONCLUSION：The experimental results showed that the composite scaffold had high porosity and compressive modulus as well as the threedimensional,connectivity network microstructures.Therefore,this composite may be one of scaffold materials for bone tissue engineering with potentially broad applicability.

关 键 词：聚磷酸钙纤维 纳米羟基磷灰石 聚乳酸 组织工程 支架 骨 复合材料 

分 类 号：R318[医药卫生—生物医学工程]