细菌对抗菌药物敏感性测定的新方法  

A new method in antimicrobial susceptibility testing

作　　者：王巍[1] 李杰[1] 刘耀川[1] 王秋霞[1] 田凯[1] 刘明春[1] 

机构地区：[1]沈阳农业大学畜牧兽医学院,沈阳110866

出　　处：《黑龙江畜牧兽医》2012年第3期26-28,共3页Heilongjiang Animal Science And veterinary Medicine

基　　金：国家自然科学基金项目(30972214);辽宁省自然科学基金项目(20082126);沈阳农业大学青年基金项目(20081020)

摘　　要：防突变浓度指防止细菌的耐药突变株被选择性富集所需的最低药物浓度,作为一种细菌敏感性测定的新方法,防突变浓度可用于预测及评估抗菌药物的防突变能力,从而使临床用药更为合理。文章就防突变浓度的测定方法、意义及其与最小抑菌浓度(MIC)、药代动力学、药效动力学的关系进行了综述,为掌握抗菌药物敏感性测定的新方法及合理使用抗菌药提供参考。The mutant prevention concentration（MPC） is defined as the lowest drug concentration which can prevent the formation of bacteria resistance mutations colony.As a new method in antimicrobial susceptibility testing,MPC testing may offer guideline for clinical medication as it can predict and evaluate the ability of antimicrobial drugs inhibiting mutant growth.In this paper,the measurement and purpose of MPC are discussed,also including their mutual effect with minimum inhibitory concentration（MIC） and pharmacokinetics/pharmacodynamics（PK/PD）.It can provide a new method in antimicrobial susceptibility testing and its clinical use.

关 键 词：细菌 敏感性 防突变浓度 耐药突变株 

分 类 号：S854.43[农业科学—临床兽医学]