复方灵芝胶囊的抗肿瘤作用研究  

Study on Anti-tumor Effect of Compound Lingzhi Capsules

作　　者：杨庆敏[1] 王宪庆[1] 赵艳[1] 张玉玺[1] 

机构地区：[1]大庆油田总医院,黑龙江大庆163001

出　　处：《中国药房》2012年第11期982-984,共3页China Pharmacy

摘　　要：目的:研究复方灵芝胶囊的抗肿瘤作用。方法:观察复方灵芝胶囊(9.00、4.50、2.25g·kg-1)对3种肿瘤细胞(S180肉瘤细胞、H22肝癌细胞与Lewis肺癌细胞)的抑制作用及与注射用环磷酰胺(CTX)、5-氟尿嘧啶(5-Fu)联合用药对S180肉瘤细胞的抑制作用。结果:9.00、4.50、2.25g·kg-1复方灵芝胶囊对小鼠S180肉瘤细胞、H22肝癌细胞与Lewis肺癌细胞生长均具有一定的抑制作用。9.00、4.50、2.25g·kg-1复方灵芝胶囊与0.01g·kg-1的CTX或5-Fu合用,与单用0.01g·kg-1CTX或5-Fu比较,对S180肿瘤的生长抑制作用更强。结论:复方灵芝胶囊对3种肿瘤的生长均有一定的抑制作用,与化疗药合用有协同作用。OBJECTIVE： To study the anti-tumor effect of Compound lingzhi capsules. METHODS： To observe the inhibition effect of Compound lingzhi capsules（9.00,4.50,2.25 g·kg^-1） on 3 kinds of tumor cells （S180 sarcoma cells, H22 liver cancer cells and Lewis lung cells）, the inhibition effect of cyclophosphamide （CTX） and 5-fluorouracil （5-Fu）with Compound lingzhi capsules on S180 sarcoma cells. RESULTS： Compound lingzhi capsules 9.00, 4.50 and 2.25 g·kg^-1 had certain inhibition effect on the growth of 3 kinds of tumor cells. Compound Lingzhi capsules 9.00,4.50 and 2.25 g·kg^-1 cooperated with CTX or 5-Fu had stronger inhibition effect on the growth of S180 than 0.01 g·kg^-1 CTX or 5-Fu alone. CONCLUSION： Compound lingzhi capsules have certain inhibition effect on the growth of 3 kinds of tumor cells, and have ability to cooperate with chemotherapy drug.

关 键 词：复方灵芝胶囊 肿瘤 小鼠 

分 类 号：R285[医药卫生—中药学] R97[医药卫生—中医学]