炉甘石炮制工艺及炮制品质量标准研究  

Study on the Processing Technology of Calamina and Quality Standard of Processed Product

作　　者：张杰红[1,2] 彭月[1,2] 施学骄[1,2] 刘友平[1,2] 

机构地区：[1]成都中医药大学,成都611137 [2]成都中医药大学中药资源系统研究与开发利用省部共建国家重点实验室培育基地,成都611137

出　　处：《中国药房》2012年第11期992-994,共3页China Pharmacy

基　　金：国家中医药管理局中医药行业科研专项中药饮片调剂规范化研究课题(201007011-10)

摘　　要：目的:优化炉甘石炮制工艺,并考察其炮制品的质量。方法:以氧化锌(ZnO)的含量为指标,采用星点设计-效应面法优选煅制工艺;显微镜下动态观察炉甘石的形态和粒径,筛选炉甘石水飞工艺;考察炮制品的外观、粒径和ZnO含量。结果:优选的炮制工艺为药物过二号筛,400℃煅烧4h,加5倍量的水研磨至糊状,再加40倍量的水搅拌,沉降8min以上,倾出上层混悬液,再加水搅拌,水飞6次,将水飞混悬液静置21h,于120℃干燥;炮制品为淡红色,粒径<200目,其ZnO的含量不低于56%。结论:所选工艺可用于炉甘石的炮制。OBJECTIVE： To optimize the processing technology of Calamina, and to investigate the quality of processed prod- uct. METHODS： The processing technology of Calamina was optimized by central composite design-response surface method using the content of ZnO as index. The dynamic observation of its shape and particle size was conducted to optimize the water grind pro- cessing of Calamina. The apperance, particle size and content of ZnO were investigated. RESULTS： The optimal processing technology was as follows： drug granularity was sifted by No.2 sieve, calcining 4 h at 400 ℃, adding 5-fold water to grind drug into paste, then adding 40-fold water to stir, resting for above 8 min to pour out the suspension. The number of water grind processing was six times, then the suspension was placed for 21 h before drying at 120 ℃. The processed product was faint red and particle size was lower than 200 mesh. The content of ZnO in processed product was no less than 56%. CONCLUSION： Optimal technology is suitable for the processing of Calamina.

关 键 词：炉苷石 氧化锌 星点设计-效应面法 炮制工艺 粒径 

分 类 号：R969.1[医药卫生—药理学] R971.1[医药卫生—药学]