红花檵木叶黄酮类化学成分的分离与鉴定  

Isolation and Identification of Flavonoid Constituents from Loropetalum chinense

作　　者：伏晓[1] 樊建领[1] 张秋颖[1] 

机构地区：[1]河南省中医院药剂科,郑州450002

出　　处：《中国药房》2012年第11期1021-1022,共2页China Pharmacy

摘　　要：目的:研究红花檵木叶中的黄酮类化学成分。方法:采用D101大孔树脂分离富集红花檵木叶乙醇提取物中的黄酮类成分,应用硅胶柱、Sephadex LH-20凝胶柱和RP-ODS柱色谱分离化合物,并通过核磁共振光谱、紫外光谱和电喷雾质谱等谱学手段鉴定化合物结构。结果:从红花檵木叶乙醇提取物中分离鉴定了5个黄酮类化合物,分别为山柰酚、槲皮素、杨梅素、杨梅素-3-O-α-L-鼠李糖苷、异槲皮苷。所有黄酮类化合物均为首次从该植物中分离得到。结论:本试验结果可为红花檵木的进一步开发利用提供科学依据。OBJECTIVE： To study the flavonoid constituents of Loropetalum chinense. METHODS： The flavonoid constituents were isolated and purified from ethanol extract of L. chinense by the column chromatography of D101 macroporous resin coupled with silica gel, Sephadex LH-20 and RP-ODS colunm chromatography. Their chemical structures of compound were elucidated by NMR, UV and ESI-MS spectral analysis. RESULTS： Five fiavonoid constituents were isolated and identified as kaempferol （1）, quercetin （2）, myricetin （3）, myricetin-3-O-a-L-rhamn-oside （4）, isoquercetin （5）. All of the flavonoid compounds were isolated from the plant for the first time. CONCLUSION： The results provide the scientific basis for further exploitation ofL. chinense.

关 键 词：红花檵木叶 黄酮 化学成分 分离 鉴定 

分 类 号：R284.1[医药卫生—中药学] R927[医药卫生—中医学]