不对称二甲基精氨酸与早产儿呼吸窘迫综合征的相关性分析  

The relationship between serum asymmetric dimethylarginine and premature respiratory distress syndrome

作　　者：黄惠娟[1] 郑铠军[1] 杨秀芳[1] 陈敬国[1] 叶春华[1] 陈玮琪[2] 

机构地区：[1]中山大学附属中山医院新生儿科 [2]中山大学附属第一医院新生儿科

出　　处：《中国中西医结合儿科学》2012年第1期19-22,共4页Chinese Pediatrics of Integrated Traditional and Western Medicine

基　　金：中山市科技计划项目资助(20102A062)

摘　　要：目的探讨不对称二甲基精氨酸(ADMA)与早产儿呼吸窘迫综合征(NRDS)的关系及脐血ADMA对预测NRDS的意义。方法以胎龄<35周、体质量<2500g的早产儿为研究对象,18例NRDS为实验组,其中分2级以上RDS组14例,1级RDS组4例;17例同期住院的早产儿为对照组。分别抽取脐带血,生后7、14d桡动脉血各2mL,用ELISA法进行ADMA检测。结果 (1)ADMA变化:早产儿胎龄、出生体质量、分娩方式,母亲合并妊娠高血压综合征与脐血ADMA无明显相关关系;(2)ADMA与NRDS的关系:2级以上RDS组脐血中ADMA明显高于1级RDS组和对照组,差异有统计学意义(P<0.05);生后7d和14d的ADMA水平各组比较差异无统计学意义(P>0.05);(3)2级以上RDS组脐血ADMA与机械通气时间、吸氧时间呈直线正相关关系(r=0.532,0.663,P<0.05)。结论脐血ADMA是独立于胎龄、出生体质量、分娩方式及母亲是否有妊娠高血压综合征的指标;脐血ADMA可能是2级以上NRDS的预测因子,脐血ADMA越高,机械通气和吸氧时间越长。Objective To investigate the relationship between ADMA and NRD5 and whether cord blood concentration of ADMA is a reliable biochemical marker to predict respiratory distress syndrome in preterm infants. Methods Eighteen preterm infants with NRDS were included in experimental group and seven- teen preterm infants whose gestation age was less then 35 weeks and birth weight was less than 2 500 g were in control group. Experimental group was divided into stage one group and stage two group. Draw 2 mL um- bilical cord blood,and then draw 2 mL of radial artery blood respectively at 7 d＇ays and 14 days after birth. All the procedures were carried out strictly according to the supplied structure manuals in the ELISA kits. Results （1）There was no linear correlation between the level of cord plasma concentrations of ADMA and birth weight,gestational age,mode of delivery and mother with hypertensive disorder complicating pregnancy. （2）In stage two group the level of cord plasma concentration of ADMA was significantly higher than that of stage one and the control group（P〈0.05）. The levels at 7 days and 14 days were not significantly different between experimental group and control group. （3）The level of cord plasma concentration of ADMA in stage two group was significantly related to length of mechanical ventilation（r= 0. 532, P〈0.05） and the length of oxygen（r=0. 663,P〈0.05）. Conclusions The level of cord plasma concentration of ADMA is negatively correlated with birth weight,gestational age,mode of delivery and mother with hypertensive disorder complicating pregnancy. ADMA may be able to predict the occurrence of stage two NRDS. The higher the level of cord plasma concentrations of ADMA,the longer the time of mechanical ventilation and oxygen inhalation.

关 键 词：不对称二甲基精氨酸 呼吸窘迫综合征 脐带血 婴儿 早产 

分 类 号：R722.6[医药卫生—儿科]