慢性氟中毒大鼠肝脏损伤的形态计量学研究  

Morhpometric Study on the damaged liver of rats with chronic fluorosis

作　　者：于燕妮[1] 曹序茂[1] 肖开棋[1] 刘万兴[1] 董仲[1] 茹景顺 

机构地区：[1]贵阳医学院病理教研室 [2]贵州省老年医学研究所

出　　处：《中国地方病学杂志》1990年第1期1-3,共3页Chinese Jouranl of Endemiology

摘　　要：本文用30ppm.60ppm 和100ppm 含氟水饲养大鼠,应用显微分光光度计测定肝脏脂肪含量及酸性磷酸酶活性。结果显示染氟大鼠肝脏脂肪含量增加,有明显脂肪变性,肌细胞灶性坏死和结缔组织增生,且肝脏酸性磷酸酶活性降低。肝脏脂肪含量与酸性磷酸酶活性的变化随给氟浓度增加而程度加重。Acid phosphatase(ACPase)activity and lipid content were studied with Uni-var microspectrotometer on the rat liver given in water containing 30ppm,60ppm,and 100ppm fluorine.The results showed that markedly increase of the lipidcontent and evidently decrease of the ACPase activity in the livers of the exp-erimental rats.Histological changes induced the focal necrosis of hepatocytes andhyperplasia of connective tissues。The changes above described were greater withthe higher dosages.

关 键 词：氟中毒 肝脏损伤 形态计量学 

分 类 号：R599.902[医药卫生—内科学]