子宫内膜异位症患者血清中EPO及ENA-78的表达及意义  

Expression and significance of serum EPO and ENA-78 in patients with endometriosis

作　　者：唐嗣信 方小玲[2] 

机构地区：[1]湖南省浏阳市妇幼保健院妇二科,湖南浏阳410300 [2]中南大学湘雅二医院妇科二病区,湖南长沙410011

出　　处：《中国现代医学杂志》2012年第2期79-81,共3页China Journal of Modern Medicine

摘　　要：目的研究促红细胞生成素(EPO)及中性粒细胞激活肽-78(ENA-78)在子宫内膜异位症中的意义及相关性。方法采用双抗体夹心酶联免疫分析方法测定34例子宫内膜异位症患者(Ⅰ、Ⅱ期12例,Ⅲ、Ⅳ期22例)和30例非子宫内膜异位症患者血清中EPO及ENA-78的表达,并分析子宫内膜异位症患者血清中E-PO及ENA-78的相关性。结果子宫内膜异位症患者血清中EPO及ENA-78的表达量均明显高于对照组(P<0.05);血清中EPO的表达量Ⅰ、Ⅱ期子宫内膜异症患者稍高于Ⅲ、Ⅳ期患者,但差异无统计学意义(P>0.05);血清中ENA-78表达量Ⅲ、Ⅳ期子宫内膜异症患者明显高于Ⅰ、Ⅱ期患者,差异有统计学意义(P<0.05);子宫内膜异症患者血清中EPO与ENA-78的表达无明显相关。结论EPO及ENA-78与子宫内膜异位症的发病有关。[Objective] To study the role and significant of serum erythropoietin （EPO） and epithelial neutrophil-activating peptide-78 （ENA-78） in patient with endometriosis. [Methods] Serum concentrations of EPO and ENA-78 were measured by means of enzyme-linked immunosobent assay （ELISA） in 34 patients with endometriosis （12 in stages I-II and 22 in stages m-iv） and in 30 women without endometriosis. And the relationship between the levels of EPO and ENA-78 in patient with endometriosis was analyzed. [Results] The serum levels of EPO and ENAre 78 in women with endometriosis were significantly higher than that in control group （P〈O.05）; there were no significant differences in the serum levels of EPO between stage I-II and III-IV （P〉O.05）; the ENA-78 concentrations of serum in stage m-iv were significantly higher than those in stage I-II （P 〈0.05）; the were no obvious correlations in serum EPO and ENA-78 in patient with endometriosis. [ Conclusion] EPO and ENA-78 involved in the pathogenesis of endometriosis.

关 键 词：子宫内膜异位症 促红细胞生成素 上皮细胞来源的中性粒细胞激活肽-78 血清 双抗体夹心酶联免疫分析法 

分 类 号：R711.71[医药卫生—妇产科学]