氟比洛芬酯复合舒芬太尼镇痛对骨科患者术后谵妄发生率的影响  

Effects of flurbiprofen axetil combined with sufentanil analgesia on the incidence of postoperative delirium in orthopedic patients

作　　者：王晓山[1,2] 刘沛[1] 王东信[1] 李世忠[3] 丁婷[1] 贾茜茜[1] 

机构地区：[1]北京大学第一医院麻醉科,100034 [2]民航总医院麻醉科 [3]北京积水潭医院麻醉科

出　　处：《临床麻醉学杂志》2012年第2期152-154,共3页Journal of Clinical Anesthesiology

摘　　要：目的观察氟比洛芬酯复合舒芬太尼镇痛对骨科患者术后谵妄发生率的影响。方法拟行择期骨科手术患者370例,年龄≥60岁,随机均分为氟比洛芬酯复合舒芬太尼组(FS组)和脂肪乳复合舒芬太尼组(S组),术后连续3d行PCIA,并随访谵妄的发生(CAM-ICU法)、VAS评分和舒芬太尼使用量。结果 FS组术后谵妄发生率明显低于S组(16.3%vs.26.2%,RR=0.62,95%CI0.41～0.93)(P<0.05)。FS组罹患谵妄的风险是S组的0.57倍(95%CI0.34～0.96)(P<0.05)。FS组术后VAS评分及舒芬太尼用量均明显低于S组(P<0.01)。结论与单纯应用舒芬太尼相比,氟比洛芬酯复合舒芬太尼镇痛能够减少骨科患者术后谵妄的发生率。Objective To investigate the efficacy of flurbiprofen axetil combined with sufentanil analgesia on prevent postoperative delirium in orthopedic patients. Methods Three hundred and seventy patients who were aged 60 years or older and underwent elective orthopedic surgery were randomized into flurbiprofen axetil plus sufentanil group （group FS） or fat emulsion plus sufentanil group（group S）. After surgery, patients were presence of delirium, the visual analog scale （ given 3 days PCIA according two groups. The VAS） and the consumptions of sufentanil were recorded. Results The incidence of delirium was significantly lower in the group FS than that in the group S （16.3% versus 26.2%, RR=0.62, 95% CI 0.41-0. 93） （P〈0. 05）. The point prevalence of delirium in the group FS was also lower compared with group S, and the risk of suffering delirium for group FS was 0. 57 times as great as that for group S （95% CI 0.34-0. 96） （P〈0.05）. The VAS scores were significantly low, the sufentanil consumptions were remarkably less in group FS than in group S. Conclusion Compare sufentanil group, group FS postoperative analgesia significantly reduce the incidence and the prevalence of delirium in orthopedic patients.

关 键 词：氟比洛芬酯 舒芬太尼 术后谵妄 术后镇痛 骨科手术 

分 类 号：R614[医药卫生—麻醉学]