婴幼儿早期喘息干预前后血、尿白三烯E4水平的变化及其临床意义  

Change of Leukotriene E4 Levels in Serum and Urine of Infants with Early Wheezing before and after Intervention and Its Clinical Significance

作　　者：马晓晖[1] 崔振泽[1] 黄燕[1] 

机构地区：[1]大连市儿童医院呼吸内科,辽宁大连116012

出　　处：《实用儿科临床杂志》2012年第4期280-282,共3页Journal of Applied Clinical Pediatrics

摘　　要：目的探讨婴幼儿早期喘息患儿急性期应用白三烯(LTS)受体拮抗剂干预后12 h、72 h血清、尿白三烯E4(LTE4)水平的变化及其临床意义。方法临床确诊为早期喘息的婴幼儿138例于入院24 h内留取血、尿标本。予口服LTS受体拮抗剂。用药后12 h,38例患儿留取血标本,77例患儿留取尿标本;用药后72 h,10例留取血标本,13例留取尿标本。分别检测干预前后其血清、尿LTE4水平,观察早期喘息婴幼儿用药干预后12 h、72 h血、尿LTE4水平的变化。结果婴幼儿早期喘息患儿干预12 h组血清LTE4水平中位数(M)为90.66 ng.L-1,四分位数间距(Q)为459.32 ng.L-1,与干预前血清LTE4水平(542.37 ng.L-1、788.65ng.L-1)比较差异有统计学意义(Pa<0.01)。婴幼儿早期喘息患儿干预后72 h组血清LTE4水平M为67.97 ng.L-1,Q为167.69ng.L-1,与干预前血清LTE4水平(310.53 ng.L-1、630.36 ng.L-1)比较差异有统计学意义(Pa<0.05)。婴幼儿早期喘息患儿干预后12 h尿LTE4水平M为7.00 ng.L-1,Q为12.74 ng.L-1,与干预前尿LTE4水平(7.84 ng.L-1、15.40 ng.L-1)比较差异无统计学意义(Pa>0.05)。婴幼儿早期喘息患儿干预后72 h尿LTE4的水平M为3.92 ng.L-1、Q为9.52 ng.L-1,与干预前尿LTE4水平(1.96 ng.L-1,5.74 ng.L-1)比较差异无统计学意义(Pa>0.05)。结论应用LTS受体拮抗剂可在短时间(≤3 d)内降低婴幼儿早期喘息患儿血清LTE4水平,但尿LTE4水平未见明显下降,提示应用LTS受体拮抗剂在短时间(≤3 d)内对尿LTE4水平影响不明显。Objective To explore the change of leukotriene E4（LTE4） levels in serum and urine in acute period of early wheezing in infants after being intervened by leukotriene（LTS） receptor antagonist for 12 h and 72 h and its clinical significance. Methods Serum and urine samples of the patients diagnosed with infant early wheezing within 24-hours hospitalization were collected,and all the patients took the LTS receptor antagonist.There were 38 patients who provided serum samples,and 77 patients who provided urine samples 12 h after medication;there were 10 patients who provided serum samples,and 13 patients who provided urine samples 72 h after medication.The concentration of LTE4 in serum and urine before and after intervention were detected respectively,and the changes of LTE4 levels in serum and urine in infant early wheezing patients after being intervened by LTS receptor antagonist for 12 h and 72 h were observed. Results The LTE4 concentration in serum in infant early wheezing group after intervention for 12 h,median（M） was 90.66 ng·L^-1 and interquartile range（Q） was 459.32 ng·L^-1.Compared with the LTE4 concentration in serum before intervention（542.37 ng·L^-1,788.65 ng·L^-1）,there was a significant discrepancy between them（Pa〈0.01）.The LTE4 concentration in serum in infant early wheezing group after intervention for 72 h,M was 67.97 ng·L^-1 and Q was 167.69 ng·L^-1,compared with the LTE4 concentration in serum before intervention（310.53 ng·L^-1,630.36 ng·L^-1）,there was a significant discrepancy between them（Pa〉0.05）.The LTE4 concentration in urine in infant early wheezing group after intervention for 12 h,M was 7.00 ng·L^-1 and Q was 12.74 ng·L^-1.Compared with the LTE4 concentration in urine before intervention（7.84 ng·L^-1,15.40 ng·L^-1）,there was no statistical discrepancy between them（Pa〉0.05）.The LTE4 concentration in urine in infant early wheezing group after intervention for 72 h,M was 3.92 ng·L^-1 and Q was 9.52 ng·L^-1.Compared with the LTE4 co

关 键 词：早期喘息 白三烯 白三烯受体拮抗剂 婴幼儿 

分 类 号：R725.6[医药卫生—儿科]