补肾活血颗粒对帕金森病患者四肢肌张力的影响  

Effects of Bushen Huoxue Granules on tension of extremity muscles of Parkinson's patients

作　　者：李敏[1] 杨明会[1] 刘毅[1] 高丽萍[1] 

机构地区：[1]中国人民解放军总医院中医研究所,北京100853

出　　处：《中华中医药杂志》2012年第3期599-602,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金："十一五"国家科技支撑计划重大项目(No.2006BAI04A11)~~

摘　　要：目的:研究补肾活血颗粒对帕金森病患者四肢肌张力的影响。方法:将60例帕金森病(PD)患者网上在线随机分成治疗组30例和安慰剂对照组30例。其中治疗组服用补肾活血颗粒,对照组服用安慰剂,每天2次,两组均以西药为基础治疗。两组患者均以3个月为治疗观察期,采用双盲设计,疗程结束后带药随访6个月观察。采用快速肌张力检测仪测量肱二头肌和股四头肌在入组时、用药3个月后及9个月后肌肉顺应性的变化,结果以压力-位移曲线线下面积来描述。评价补肾活血颗粒对PD患者四肢肌张力的影响。结果:在治疗观察期中治疗组单侧肱二头肌和股四头肌肌张力有明显改善(P<0.05),在随访观察期中治疗组双侧的肱二头肌和股四头肌肌张力均较对照组有改善(P<0.05,P<0.01)。研究过程中未发现明显不良反应。结论:补肾活血颗粒可以降低PD患者肱二头肌和股四头肌静息状态肌张力,对最大自主收缩状态下肌张力无明显改变。Objective： To study the effects of Bushen Huoxue Granules on muscular tension in Parkinson’s patients.Methods： 60 patients were enrolled and divided into two groups randomly,the control group were treated with placebo and treatment group with Bushen Huoxue Granules,both groups based on Madopar treatment.Double-blinded clinical trial was adopted in treatment period.Follow-up period for 6 months,Myotonometer？ was adopted to measure muscular tension changes of the biceps and quadriceps at baseline time after 3 months and after 9 months.Area under curve（AUC） was used to describe the changes of muscular tension.Results： Bushen Huoxue Granules treatment group showed a higher efficacy than the placebo group in relieving the motor function obstacle of Parkinson,s patients,from the aspects of both biceps and quadriceps（P〈0.05,P〈0.01）.No adverse effects were found in this trial.Conclusion： Bushen Huoxue Granules can markedly relieve static muscular tension of biceps and quadriceps in Parkinson’s patients.There was no significant muscular tension changes in Maximum Voluntary Contraction state.

关 键 词：帕金森病 补肾活血颗粒 肌张力 

分 类 号：R277.7[医药卫生—中医学]