葛根素提取物口腔崩解片的制备及质量评价  

Preparation and quality evaluation of puerarin extract oral disintegrating tablets

作　　者：景荣琴 景怡[2] 胡天慧[3] 

机构地区：[1]甘肃省白银市第二人民医院,白银730900 [2]江苏淮阴工学院,淮安223003 [3]淮安市淮阴区第二人民医院,淮安223003

出　　处：《中华中医药杂志》2012年第3期750-752,共3页China Journal of Traditional Chinese Medicine and Pharmacy

摘　　要：目的:制备葛根素提取物口腔崩解片并对其质量进行评价。方法:采用单因素法优选压力和矫味剂;采用正交试验法优选崩解剂。结果:优选的处方为葛根素提取物22%,交联聚乙烯吡咯烷酮(PVPP)10%,微晶纤维素(MCC)40%,硬度在4.0-5.0kg,桔子香精:甘露醇:阿司帕坦比例为0.8:5:1,制得的口腔崩解片在30s内崩解完全,口感良好。结论:本处方和工艺制得的葛根素提取物口腔崩解片质量优良,达到设计要求。Objective： Prepare puerarin extract oral disintegrating tablets and evaluate its quality.Methods： Single-factor method was adopted to optimize the pressure,lubricant and correctant;orthogonal design was adopted to optimize the disintegrant agent.Results： The optimized formulation was as follows： 22% puerarin,10% cross-linked polyvinylpyrrolidone,40% microcrystalline cellulose,hardness was 4.0-5.0kg,orange flavor：mannitol：aspartame ratio was 0.8：5：1.The prepared tablets disintegrated totally within 30s and tasted good.Conclusion： The puerarin extract oral disintegrating tablets obtained by this prescription and process have good qualities and meet the design requirements.

关 键 词：葛根素 口腔崩解片 崩解时间 质量评价 

分 类 号：TQ461[化学工程—制药化工] R286[医药卫生—中药学]