广藿香醇的急性毒性研究  

Acute Toxicity of Patchouli Alcohol

作　　者：何景进[1,2] 彭绍忠[1,2] 谢庆凤[1,2] 黎玉翠[1,2] 苏冀彦[1,2] 赖小平[1,2] 苏子仁[1,2] 

机构地区：[1]广州中医药大学,广东广州510006 [2]东莞广州中医药大学中医药数理工程研究院,广东东莞523808

出　　处：《时珍国医国药》2012年第2期274-275,共2页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(No.U0732004);国家科技重大专项(No.2009ZX09103-376)

摘　　要：目的观察广藿香醇对小鼠的急性毒性,评价其安全性,为新药研发和临床用药提供理论依据。方法采用口服和腹腔注射给药途径,观察小鼠给予不同剂量广藿香醇花生油溶液后的死亡率,Bliss法计算半数致死量。结果广藿香醇花生油溶液的灌胃给药的LD50是4.693 g/kg,95%的置信区间上限是5.498 g/kg,下限是4.038 g/kg;广藿香醇花生油溶液的腹腔注射给药的LD50是3.145 g/kg,95%的置信区间上限是3.675 g/kg,下限是2.663 g/kg。结论广藿香醇的安全性较高,属于低毒药物。Objective To investigate the acute toxicity of patchouli alcohol in mice and to evaluate its safety. Methods The mortality rates of oral and intragastric administration of patchouli alcohol dissolved by arachis oil were observed and the LD50 was determined by Bliss assay. Results The LD50 of patchouli alcohol by oral and intragastric administration in mice was 4. 693g/kg body weight and 3. 145g/kg body weight, respectively. Conclusion Patchouli alcohol is a low toxic drug.

关 键 词：广藿香醇 急性毒性 半数致死量 

分 类 号：R285.5[医药卫生—中药学]