黄萸方防治大鼠早期糖尿病肾病足细胞损伤的研究  

Effect of Huang-Yu Fang on Podocyte Damage in Early Diabetic Nephropathy Rats

作　　者：李佑生[1,2] 杨磊 王文健 刘毅[3,4] 何燕铭[5] 陈伟华[3,4] 应健[3,4] 

机构地区：[1]暨南大学第二临床医学院 [2]深圳市人民医院,广东深圳518020 [3]复旦大学中西医结合研究所 [4]复旦大学附属华山医院,上海200040 [5]上海中医药大学附属岳阳中西医结合医院,上海200437

出　　处：《时珍国医国药》2012年第2期299-301,共3页Lishizhen Medicine and Materia Medica Research

基　　金：广东省自然科学基金(No.8151802001000010)

摘　　要：目的观察中药复方黄萸方对实验性糖尿病大鼠微量白蛋白尿的疗效,及对足细胞的影响。方法采用高糖高脂喂饲加低剂量STZ诱导伴胰岛素抵抗的大鼠2型糖尿病,给予黄萸方治疗12周,观察血糖及尿微量白蛋白,采用透射电镜及图像分析技术,观察对足细胞形态的影响。结果黄萸方可降低血糖、减少尿微量白蛋白,同时可改善足细胞损伤,疗效优于ARB。结论黄萸方可改善实验性大鼠2型糖尿病肾脏病变,主要是改善足细胞损伤,减少微量白蛋白尿。Objective To explore the effect of Huang -Yu Fang （HYF） on urinary micro -albumin in experimental early diabetic rats, especially on podocyte damage. Methods Rats were fed a high glucose and high fat diet and given a low dose of STZ to develop type 2 diabetes with insulin resistance, and then treated with HYF 12 weeks. Blood glucose, urinary micro -albumin and other targets were measured, as well as the morphology of podoeytes were observed by transmission electron microscope. Results HYF could decrease blood glucose level, reduce urinary micro - albumin, and ameliorate the reduction of podocyte number and the podocytes fusion. These effects were better than ARB. Conclusion HYF has beneficial renoprotective effect on progression of type 2 diabetic nephropathy in rats, and the main effect is ameliorating the reduction of podoeyte number and the podocytes fusion, and reducing urinary micro -albuminuria.

关 键 词：黄萸方 糖尿病肾病 微量白蛋白尿 胰岛素抵抗 足细胞 

分 类 号：R284.2[医药卫生—中药学]