线性扫描极谱法测定辛伐他汀  

Linear Scanning Polarographic Determination of Simvastatin

作　　者：丘则海[1] 吴粦华[1] 胡志彪[1] 周云龙[1] 拓宏桂[1] 

机构地区：[1]龙岩学院化学与材料学院,龙岩364000

出　　处：《理化检验（化学分册）》2012年第2期226-228,共3页Physical Testing and Chemical Analysis(Part B:Chemical Analysis)

基　　金：福建省教育厅B类项目资助(JB09220)

摘　　要：用线性扫描极谱法研究辛伐他汀的电化学行为。在pH 6.88的0.12mol·L-1磷酸氢二钠-磷酸二氢钾缓冲溶液中,辛伐他汀于-1.188V(vs.SCE)处产生一灵敏的吸附波,其一次微分线性扫描峰电流与辛伐他汀质量浓度在0.01～5.0mg·L-1范围内呈线性关系,检出限(3S/N)为7.0μg·L-1。对5.0mg·L-1辛伐他汀溶液进行6次平行试验,相对标准偏差(n=6)为0.53%,方法可用于测定其片剂中辛伐他汀含量。It was found that in a PBS of pH 6. 88 and by the linear scanning polarography, a sensitive adsorption wave of simvastatin was observed at the potential of -1. 188 V （vs. SCE）. Linear relationship between values of 1st derivative of the peak current and mass concentration of simvastatin was obtained in the range of 0. 01-5.0 mg · L^-1 with detection limit （3S/N） of 7. 0 μg · L^-1. Precision was tested with standard solution of simvastatin of 5.0 mg · L^-1 for 6 determinations, value of RSD （n=6） found was 0. 53%. The proposed method has been used in the determination of content of simvastatin in its tablets.

关 键 词：辛伐他汀 线性扫描极谱法 吸附波 

分 类 号：O657.14[理学—分析化学]