Syntheses and studies of hydantoin derivatives as potential anti-tuberculosis inhibitors  

作　　者：Yan Liu Wu Zhong Song Li 

机构地区：[1]School of Pharmaceutical Engineering,Shenyang Pharmaceutical University,Shenyang 110016,China [2]Laboratory of Computer-Aided Drug Design&Discovery,Beijing Institute of Pharmacology and Toxicology,Beijing 100850,China

出　　处：《Chinese Chemical Letters》2012年第2期133-136,共4页中国化学快报（英文版）

基　　金：supported by the National High Technology Research and Development Program of China(No2006AA020601)

摘　　要：A short and efficient synthesis of（Z）-2-substituted-5-（4-（（2-substitued-5-oxoimidazolidin-4-ylidene）methyl）benzamido）ben-zoic acid derivatives（8a-g） as potential type of FabH inhibitors is described.Their structures were confirmed by MS,NOE and ~1H NMR.A short and efficient synthesis of（Z）-2-substituted-5-（4-（（2-substitued-5-oxoimidazolidin-4-ylidene）methyl）benzamido）ben-zoic acid derivatives（8a-g） as potential type of FabH inhibitors is described.Their structures were confirmed by MS,NOE and ~1H NMR.

关 键 词：Tuberculosis Mycobacterium tuberculosis FabH Enzyme inhibitor Synthesis NOE 

分 类 号：TQ252.4[化学工程—有机化工] O636.1[理学—高分子化学]