A copper- and amine-free Sonogashira reaction employing chlorophosphine as new and efficient ligand  

作　　者：Wen Peng Mai Jin Wei Yuan Zhi Cheng Li Gang Chun Sun 

机构地区：[1]Chemistry and Chemical Engineering School,Henan University of Technology,Zhengzhou 450001,China

出　　处：《Chinese Chemical Letters》2012年第2期185-188,共4页中国化学快报（英文版）

基　　金：Henan University of Technology for financial support(The Introduction of Talent Fund)

摘　　要：An efficient palladium-catalyzed copper- and amine-free Sonogashira coupling reaction of aryl bromides and chlorides was studied using a sterically hindered monooxychlorophosphine as new ligand.The use of 2 mol%Pd（OAc）_2 in the presence of K_2CO_3 allows the coupling reaction to proceed at mild condition with good to excellent yields.An efficient palladium-catalyzed copper- and amine-free Sonogashira coupling reaction of aryl bromides and chlorides was studied using a sterically hindered monooxychlorophosphine as new ligand.The use of 2 mol%Pd（OAc）_2 in the presence of K_2CO_3 allows the coupling reaction to proceed at mild condition with good to excellent yields.

关 键 词：Palladium Copper-free Coupling Sonogashira reaction Chlorophosphine 

分 类 号：O641.4[理学—物理化学] O623.731[理学—化学]