Potentiometric sensor for sensitive and selective detection of heparin  

作　　者：Yan Chen Rong Ning Liang Wei Qin 

机构地区：[1]CAS and Shandong Provincial Key Laboratory of Coastal Zone Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China [2]Graduate University of the Chinese Academy of Sciences, Beijing 100049, China

出　　处：《Chinese Chemical Letters》2012年第2期233-236,共4页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(No41176081);the Outstanding Youth Natural Science Foundation of Shandong Province(NoJQ200814);the Taishan Scholar Program of Shandong Province(NoTS20081159)

摘　　要：A polymeric membrane ion-selective electrode for determination of heparin is described in this paper.Protamine is incorporated into the organic membrane phase and functions as sensing element for selective recognition of heparin.The proposed membrane electrode exhibits high selectivity for heparin over lipophilic anions such as thiocyanide and salicylate.The potentiometric response to the concentration of heparin is Unear in the range of 0.01-0.4 U/mL and a lower detection limit of 0.005 U/mL can be achieved.A polymeric membrane ion-selective electrode for determination of heparin is described in this paper.Protamine is incorporated into the organic membrane phase and functions as sensing element for selective recognition of heparin.The proposed membrane electrode exhibits high selectivity for heparin over lipophilic anions such as thiocyanide and salicylate.The potentiometric response to the concentration of heparin is Unear in the range of 0.01-0.4 U/mL and a lower detection limit of 0.005 U/mL can be achieved.

关 键 词：Potentiometry Sensing element Heparin Protamine Polyion sensor 

分 类 号：TQ464[化学工程—制药化工] TP212[自动化与计算机技术—检测技术与自动化装置]