多西他赛联合顺铂治疗晚期食管癌的临床观察  

Docetaxel Plus Cisplatin for Patients with Advanced Esophageal Cancer:A Clinical Observation

作　　者：林丹霞[1] 邱希辉[1] 江艺[1] 陈志明[1] 杨钰贤[1] 林慧[1] 

机构地区：[1]汕头大学医学院附属肿瘤医院中西医结合科,广东汕头515031

出　　处：《中国医院用药评价与分析》2012年第2期152-154,共3页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：广东省汕头市重点科技计划项目(编号:汕府科[2009]70号)

摘　　要：目的:观察多西他赛(DOC)联合顺铂(DDP)治疗初治及复治晚期食管癌患者的客观疗效和不良反应。方法:应用TP方案:DOC 75 mg.m-2,静脉滴注,d1;DDP 30 mg.m-2,d1～8,静脉滴注。初治组28例,复治组32例,其中食管鳞癌56例,食管低分化癌3例,食管腺鳞癌1例,均为Ⅳ期患者,每例患者接受2个周期以上方可评价疗效。结果:60例患者均可评价疗效和不良反应,初治组有效率为50.0%(14/28),疾病控制率为67.9%(19/28),中位疾病进展时间(TTP)为4.9个月。复治组有效率为25.0%(8/32),疾病控制率为62.5%(20/32),中位TTP为4.7个月。2组的有效率比较,差异有统计学意义(P<0.05),2组的中位TTP比较,差异无统计学意义(P>0.05)。主要不良反应为骨髓抑制、消化道反应及脱发。结论:DOC联合DDP是治疗初治与复治晚期食管癌的有效方案,初治者可显著提高疗效,不良反应均可耐受。OBJECTIVE： To evaluate the efficacy and toxicity of docetaxel（DOC） plus cisplatin（DDP） in initial treatment or retreatment of patients with advanced esophageal cancer.METHODS： A total of 60 patients with advanced esophageal cancer（stage Ⅳ） including 56 cases of squamous cancer,3 cases of poorly differentiated cancer and 1 case of squamous cancer were enrolled with 28 in initial treatment group and 32 in retreatment group.All patients were treated with TP regimen,i.e.docetaxel（75 mg·m-2） on day 1 plus DDP（30 mg·m-2） from day 1 to day 8 all by i.v drip infusion.After treatment of at least 2 cycles,the efficacy was evaluated.RESULTS： Efficacy and safety evaluation could be performed in all the 60 patients.In the initial treatment group vs.retreatment group,the effective rate was 50.0%（14/28） vs.25.0%（8/32）（P0.05）;the rate of disease control was 67.9%（19/28） vs.62.5%（20/ 32）,and the median time to progression（TTP） was 4.9 months vs.4.7 months（P0.05）.The major adverse reactions included bone marrow suppression,reactions of digestive tract and alopecia.CONCLUSION： Docetaxel（DOC） in combination with cisplatin（DDP） was proved to be an effective regimen with remarkably improved efficacy and tolerable toxicity in both initial treatment and retreatment of patients with advanced esophageal cancer.

关 键 词：晚期食管癌 药物疗法 多西他赛 顺铂 化学治疗 

分 类 号：R979.1[医药卫生—药品]