子宫内膜异位症患者RBP4与ENA-78的含量变化  

Changes of Levels of Prostaglandin Retinol Binding Protein 4(RBP4) and Epithelial Neutrophil-Activing Peptide-78(ENA-78) in Peritoneal Fluid and Serum of Patients with Endometriosis

作　　者：张文敏[1] 赵艳丽[2] 班开斌[1] 黄友敏[3] 

机构地区：[1]山东省滕州市中心人民医院妇产科,277500 [2]山东省滕州市妇幼保健院妇产科 [3]山东省滕州市中心人民医院输血科,277500

出　　处：《中华全科医学》2012年第3期384-385,共2页Chinese Journal of General Practice

摘　　要：目的探讨子宫内膜异位症(EMS)患者腹腔液及血清中视黄醇结合蛋白4(RBP4)和中性粒细胞激活肽-78(ENA-78)的含量变化及其与EMS发病的关系。方法采用酶联免疫吸附法(ELISA)检测86例EMS患者和36例因卵巢囊肿或浆膜下子宫肌瘤手术患者腹腔液及血清RBP4和ENA-78含量并进行分析。结果 EMS组患者腹腔液中RBP4、ENA-78的含量明显高于对照组,两组比较差异均有统计学意义(P<0.01)。Ⅲ、Ⅳ期EMS患者腹腔液及血清中RBP4的含量较Ⅰ、Ⅱ期患者明显升高,差异也有统计学意义(P<0.01);Ⅲ、Ⅳ期EMS患者腹腔液及血清中ENA-78的含量较Ⅰ、Ⅱ期患者升高,差异有统计学意义(P<0.05)。同时EMS组患者RBP4与ENA-78的含量之间存在正相关(r=0.72,P<0.01)。结论 EMS患者腹腔中高含量的RBP4与ENA-78,可能对EMS发病有影响;EMS患者腹腔液与血清中RBP4和ENA-78含量变化且与EMS关系密切。Objective To investigate the concentrations of prostagland in retinol binding protein 4 （RBPg） and epithelial neutrophil-activing peptide-78 （ENA-78） in serum and peritoneal fluid of women with endometriosis. Methods The study group included 86 samples of peritoneal fluid and serum respectively from patients with endometriosis, and control group included 36 samples of peritoneal fluid and serum respectively from patients without endometriosis（ either ovary cyst or uterine myoma）. The peritoneal fluids were collected at the time of laparoscopic operation, and the sera were collected before surgery. Concentrations of RBP4 and ENA-78 were determined by enzyme linked immunosorbent assay （ELISA）. Results The peritoneal fluid concentra- tions of RBP4 and ENA-78 in study group were significantly higher than those of control group（P 〈 0.01 ） ;and the RBP4 levels of stage Ⅲ, Ⅳ in endometriosis group were significantly higher than those of stage Ⅰ , Ⅱ in endometriosis group in serum and peritoneal fluid（P 〈 0.01 ） ;and the ENA-78 levels of stage III, IV in endometriosis group were significantly higher than those of stage Ⅰ ,Ⅱ in endometriosis group in serum and peritoneal fluid（P 〈0.01 ）. There was positive correlation between the concentrations of RBP4 and ENA-78 in endometriosis group（r = 0.72, P 〈 0.01 ）. Conclusion The concentrations of RBP4 and ENA- 78 in peritoneal fluid were increased in endometriosis. The concentrations of RBP4 and ENA-78 were associated with the extent of endometrosis lesions.

关 键 词：子宫内膜异位症 视黄醇结合蛋白4 中性粒细胞激活肽-78 

分 类 号：R711.71[医药卫生—妇产科学]