血清HB-EGF对冠状动脉支架内再狭窄的影响  

Influence of the Level of HB-EGF in Serum on Instent Restenosis after CHD Stenting

作　　者：阚振[1] 袁争百 苏振琪 谢伟[1] 韩宏华[1] 

机构地区：[1]安徽省淮北市矿工总医院心内科,235000

出　　处：《中华全科医学》2012年第3期398-399,共2页Chinese Journal of General Practice

摘　　要：目的探讨血清肝素结合表皮生长因子样生长因子(HB-EGF)水平对冠状动脉支架内再狭窄的影响。方法选取2009～2010年在淮北市矿工总医院复查造影的既往接受PCI术患者80例进行研究。以支架内狭窄≥50%为再狭窄标准,将患者分为再狭窄组36例及非再狭窄组44例。所有患者均于造影前采空腹血,测定血清中HB-EGF水平。结果再狭窄组血清HB-EGF水平显著高于非再狭窄组,差异有统计学意义(P<0.05),多因素Logistic回归分析显示:血清中HB-EGF水平的B:0.112,OR:1.025,95%CI:0.989～1.250(P<0.05)。结论血清中HB-EGF水平升高促进了支架内的内膜增殖及血管重构,是冠状动脉支架内再狭窄的危险因素之一。Objective To investigate the effect of the level of HB-EGF in serum on instent restenosis after CHD stenting. Methods A Total of 36 patients with in-stem restenosis and 44 patients free from restenosis confirmed by radiography were enwiled in this study. The level of HB-EGF in serum was compared between the two groups. Results The level of HB-EGF in the group of in-stent restenosis was higher than that in the group of non in-stem restenosis. Logistic regression analysis showed that the level of HB-EGF in serum sensitivity index B = 0.112, OR = 1. 025,95% CI 0. 989 - 1. 250 （ P 〈 0.05 ）. Conclusion The resuits suggested that the level of HB-EGF in serum was positively correlated to in-stent restenosis, the level of HB-EGF in serum can promote endotheliocyte proliferation and reconstruction of blood vessel.

关 键 词：肝素结合表皮生长因子样生长因子 再狭窄 冠状动脉支架 

分 类 号：R541.4[医药卫生—心血管疾病]