纳米银温敏喷雾凝胶与环丙沙星联合应用体外抑菌作用  

THE ANTIBACTERIAL EFFECT OF TEMPERATURE-SENSITIVE GEL CONTAINING SILVER NANOPARTICLES COMBINED WITH CIPROFLOXACIN in vitro

作　　者：陈美婉[1,2,3] 刘长秀[4] 余思琴[1,2] 杨志文[1,2] 吴传斌[1,2] 

机构地区：[1]中山大学药学院,广州510006 [2]广东省创新药物制剂工程技术研究开发中心 [3]澳门大学中华医药研究院 [4]中山大学基础医学实验教学中心

出　　处：《中国消毒学杂志》2012年第1期18-19,22,共3页Chinese Journal of Disinfection

摘　　要：目的观察纳米银温敏喷雾凝胶与环丙沙星联合应用的体外抑菌作用,探讨其抗菌应用价值。方法用K-B纸片扩散法,对上述两种制剂联合应用抑菌效果进行了测定。结果纳米银温敏喷雾凝胶抗菌效果良好,可以增强环丙沙星对金黄色葡萄球菌,大肠埃希菌和铜绿假单胞菌的抑制作用。结论纳米银温敏喷雾凝胶联用环丙沙星体外的联合应用具有良好的可行性。Objective To study the antibacterial effect of temperature - sensitive gel containing silver nanoparticles combined with ciprofloxacin in vitro and to investigate its potential value. Methods The K - B test was used to observe the antibacterial effect of temperature - sensitive gel containing silver nanopartieles combined with ciprofloxacin. Results The temperature - sensitive gel containing silver nanoparticles could strengthen the antibacterial activity of ciprofloxaein against Staphylococcus auresus, Escherichia coli, and Pseudomonus aeruginosa. Conclusion The application of temperature - sensitive gel containing silver nanoparticles combined with eiprofioxacin in vitro is feasible.

关 键 词：纳米银 喷雾凝胶 环丙沙星 联合应用 抑菌作用 

分 类 号：R187.1[医药卫生—流行病学]