马钱子碱固体脂质纳米粒的制备研究  

Studies on Preparation of Brucine Solid Lipid Nanoparticles

作　　者：苑娟[1] 万焱[1] 王宪龄[1] 

机构地区：[1]河南中医学院药学院,河南郑州450008

出　　处：《中医学报》2012年第3期336-337,共2页Acta Chinese Medicine

基　　金：河南省教育厅自然科学基础研究计划项目(编号:2010A360020);郑州市科技攻关项目(编号:10PTGS486-5)

摘　　要：目的:制备马钱子碱固体脂质纳米粒,并优化其处方组成。方法:采用乳化蒸发-低温固化法制备马钱子碱固体脂质纳米粒,以包封率为指标,通过正交试验对处方进行优化。结果:制备的纳米粒为类球形,包封率为58.06%,平均粒径为189nm,Zeta电位为-28.91 mV。结论:本实验建立的方法简便、快捷、稳定,可用于制备马钱子碱固体脂质纳米粒。Objective:To prepare brucine solid lipid nanoparticles and optimize the formulation.Methods:The brucine solid lipid nanoparticles were prepared by means of emulsification-solvent evaporation method.With the entrapment efficiency as reference,the best formulation was optimized by orthogonal design.Results:Brucine solid lipid nanoparticles were spherical shape with mean diameter of 189 nm,entrapment efficiency(EE) of 58.06%,and the zeta potential of 28.91 mV.Conclusion:The method established in this paper is simple,accurate and stable,can be used to prepare brucine solid lipid nanoparticles successfully.

关 键 词：马钱子碱 固体脂质纳米粒 正交实验 包封率 高效液相色谱法 

分 类 号：R285.1[医药卫生—中药学]