纤维连接蛋白基因型多态性与草酸钙肾结石相关性研究  

Research about the Relationship between Fibronectin Gene Polymorphisms and Calcium Oxalate Nephrolithiasis

作　　者：张新涛[1] 史明[1] 王风[1] 常江平[1] 梅红兵[1] 

机构地区：[1]深圳市第二人民医院泌尿外科,广东深圳518035

出　　处：《深圳中西医结合杂志》2012年第1期17-20,共4页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

基　　金：深圳市科技局计划项目(201003040)

摘　　要：目的:探讨纤维连接蛋白基因(FN)型多态性与草酸钙肾结石的关系。方法:用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)方法,检测所有研究对象的FN第2内含子rs10202709位点及第26内含子rs35343644位点的基因型,探讨其基因型与草酸钙肾结石的关系。结果:FNAA基因型与草酸钙肾结石的发病率相关(P<0.05),未发现其他基因型与草酸钙肾结石有相关性。结论:FN基因型多态性与草酸钙肾结石有相关性,FN的AA基因型可作为肾结石患者草酸钙结石危险因素的标志。Objective To explore the relationship between fibronectin （FN） gene polymorphisms and calcium oxalate nephrolithiasis. Methods Fibronectin （FN） genetic polymorphisms of the introns 2 rs10202709 and introns 26 rs35343644 nucleotides were analyzed by polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP）, so as to analyze the correlations between the polymorphisms of the FN genotypes and calcium oxalate nephrolithiasis. Results Fibronectin （FN） AA genotype showed a correlation with the incidence of calcium oxalate nephrolithiasis （P 〈 0.05）, and other genotype showedno correlation. Conclusion The polymorphism of fibronectin （FN） appears to be associated with the calcium oxalate nephrolithiasis, and the AA genotype may be a good marker for evaluating the genetic risks in patients with nephrolithiasis

关 键 词：纤维连接蛋白 基因型多态性 草酸钙 肾结石 

分 类 号：R691.4[医药卫生—泌尿科学]