SULT1A1基因多态性与子宫肌瘤关系  

Correlation between SULT1A1 genetic polymorphism and uterine leiomyoma

作　　者：林林[1] 相静[1] 韩春蕾[1] 张英姿[1] 周超[1] 

机构地区：[1]滨州医学院流行病学教研室,山东烟台264003

出　　处：《中国公共卫生》2012年第3期315-317,共3页Chinese Journal of Public Health

基　　金：山东省高等学校科技计划项目(J10LF70)

摘　　要：目的了解硫酸基转移酶(SULT)1A1基因Arg 213His多态性与子宫肌瘤的关系,为预防子宫肌瘤的发病提供参考依据。方法采用以医院为基础的1:1病例对照研究方法对2009年8-10月在山东省滨州医学院附属医院妇产科就诊的123例子宫肌瘤患者和123名同期进行体检的健康女性进行流行病学调查和分子生物学检测。结果病例组和对照组SULT1A1基因Arg213His位点野生型(G/G)、突变型杂合子(G/A)、突变型纯合子(A/A)3种多态基因型频率分别为58.5%3、9.0%、2.5%和76.4%、22.0%、1.6%,2组多态基因型频率间差异有统计学意义(χ2=9.085,P=0.011);与G/G基因型比较,G/A、A/A和突变型(G/A+A/A)基因型个体发生子宫肌瘤的相对危险度OR值分别为2.321(95%CI=1.322～4.074)、1.958(95%CI=0.319～12.03)和2.296(95%CI=1.325～3.978);多因素Logistic回归分析结果表明,高血压病史、负性生活事件、既往阴道炎、既往盆腔炎、既往宫颈炎、一级亲属患子宫肌瘤、口服避孕药、人工流产史和SULT1A1基因Arg213His位点突变基因型是子宫肌瘤发生的危险因素,初潮年龄>12岁是子宫肌瘤发生的保护因素。结论 SULT1A1基因Arg213His位点突变基因型个体子宫肌瘤发病风险明显增加;有效防治慢性妇科炎症、高血压病、减少负性生活事件刺激等可以减少子宫肌瘤的发生。Objective To assess genetic polymorphism of sulfortransferase lAl（SULT1A1） Arg213His and its relationship with the incidence of uterine leiomyoma.Methods Epidemiological questionnaire survey and molecular biology detection were conducted in a hospital-based 1∶ 1 case-control study with 123 uterine leiomyoma patients and 123 healthy female examinees recruited from Affiliated Hospital of Binzhou Medical College from August to October 2009.ResultsThere was a significant difference（χ2=9.085,P=0.011） in the SULT1A1 Arg213His polymorphism between uterine leiomyoma patients and control subjects.The frequencies of wild-type（G/G）,mutant heterozygotes（G/A）,and homozygous mutant（A /A） in the two groups were 58.5%,39.0%,2.5% and 76.4%,22.0%,1.6%,respectively.Compared with G/G genotype,the odds ratio of suffering from uterine leiomyoma for the individuals with G/A,A/A,and G/A＋A/A genotypes were 2.321（95% confidence interval：1.322,4.074）,1.958（95%CI：0.319,12.03）,and 2.296（95%CI：1.325,3.978）,respectively.Multivariate logistic regression analyses showed that the risk factors of uterine leiomyoma included pelvic inflammation,stressful life event,hypertension,induced abortion,oral contraceptive use,with mother or sister suffering from uterine leiomyoma,vaginitis,cervicitis,and polymorphism of SULT1A1 gene,whereas the delayed menstruation was proved to be a protective factor of the disease.Conclusion The Arg213His genetic polymorphism of SULT1A1 is a risk factor for the incidence of uterine leiomyoma.And it can be controlled by prevention and treatment of gynecological inflammation,hypertension and stressful life events.

关 键 词：子宫肌瘤 硫酸基转移酶1A1 基因多态性 

分 类 号：R711.74[医药卫生—妇产科学]