先天性胆管扩张症癌变及其治疗  

Malignant change of congenital biliary dilatation and its treatment

作　　者：陈燕凌[1] 韩圣华[1] 

机构地区：[1]福建医科大学附属协和医院肝胆外科,福建福州350001

出　　处：《中国实用外科杂志》2012年第3期196-198,共3页Chinese Journal of Practical Surgery

摘　　要：先天性胆管扩张症是一种癌前病变,胰胆管合流异常在癌变过程中起着重要的作用,癌变率随年龄增长明显增高。对确诊先天性胆管扩张症的病人,应尽早行扩张胆管的彻底切除、胆囊切除、肝管空肠Roux-en-Y吻合术以预防癌变的发生。先天性胆管扩张症癌变缺乏特异性临床表现,术前诊断困难,预后不佳。对可疑病例应行术中冰冻快速病理检查,确诊癌变者应按胆管癌的治疗原则进行处理,对失去根治机会者,姑息性手术方式可以缓解症状和提高生活质量。Congenital biliary dilatation (CBD) is a premalignant lesion. Pancreaticobiliary maljunction plays important roles in the process of malignant change. The incidence of malignant change increases obviously with age.Complete cyst excision with cholecystectomy and Roux-en-Y hepaticojejunostomy is required as soon as a diagnosis is made to interrupt the cancerous potential. The clinical symptom of malignant change of CBD is nonspecific.Preoperative diagnosis is difficult and the prognosis is poor.The intraoperative frozen section should be performed to rule out the presence of cancer. The operation for carcinoma of the bile duct should be performed in CBD with malignant change. Palliative surgery should be considered to relieve symptom and improve survival in patients with unresectable disease.

关 键 词：先天性胆管扩张症 癌变 

分 类 号：R6[医药卫生—外科学]