肿瘤坏死因子受体p55、p75在创伤患者体内的表达及其临床意义  

The expression of TNFR p55 and p75 in trauma patients and its clinical significances

作　　者：刘畅[1] 唐建伟[1] 

机构地区：[1]复旦大学附属金山医院急诊外科,上海200540

出　　处：《临床急诊杂志》2012年第1期43-45,共3页Journal of Clinical Emergency

摘　　要：目的:探讨创伤患者体内肿瘤坏死因子受体p55、p75的表达及其意义。方法:用流式细胞仪和ELISA法检测不同创伤程度患者外周血中肿瘤坏死因子受体p55、p75的表达情况,以健康献血者为对照。结果:创伤患者较健康献血者血浆和血白细胞中p55、p75的表达明显增高(P<0.05),而且创伤程度愈严重者,其p55、p75的表达愈增高。结论:创伤导致肿瘤坏死因子受体p55、p75表达增高,而且与创伤严重程度存在一定相关性(P<0.05)。Objective：To investigate the expression changes of TNFR p55 and p75 in trauma patients and its significance. Method： The expression of p55 and p75 in plasma and leukocytes were determined by ELISA and FCM individually, and these data were compared with the control group . Result： The expression of p55 and p75 in plasma and leukocytes were higher in traumatic group than those in the normal controls （P〈0.05）. Conclusion：The levels of p55 and p75 increase in traumatic patients, and there is a direct correlation between the concentrations of p55and p75 and traumatic severity （P〈0.05）.

关 键 词：创伤 肿瘤坏死因子受体1(p55) 肿瘤坏死因子受体2(p75) 

分 类 号：R64[医药卫生—外科学]