Synthesis, Antibacterial Activities and Nuclease Properties of Ternary Copper（II） Complex Containing 2-（2＇-Pyridyl）benzothiazole and Glycinate  

作　　者：Lu,Yanmei Chen,Yongheng ou,Zhibin Chen,Shi Zhuang,Chuxiong Le,Xueyi 

机构地区：[1]Department of Applied Chemistry,South China Agricultural University,Guangzhou,Guangdong 510642,China [2]College of Life-Science,South China Agricultural University,Guangzhou,Guangdong 510642,China [3]Institute of Biomaterial,South China Agricultural University,Guangzhou,Guangdong 510642,China

出　　处：《Chinese Journal of Chemistry》2012年第2期303-310,共8页中国化学（英文版）

基　　金：We are thankful for the Natural Science Foundation of Guangdong Province （No. 10151064201000016） and the 211 Project Program Foundation of South China Agricultural University （No. 2009B010100001）.

摘　　要：A new ternary complex [Cu（PBT）（Gly）（H2O）]ClO4 （PBT=2-（2＇-pyridyl）benzothiazole, and Gly=glycinate） has been synthesized and characterized by elemental analysis, molar conductivity, and IR methods. The complex, structurally characterized by single-crystal X-ray crystallography, shows a slightly distorted square-pyramidal coordination geometry in which two nitrogen atoms of PBT and the carboxylate oxygen atom O and the amino nitrogen atom N of Gly bind at the basal plane, a water molecule is coordinated at the apical position. The complex, Cu（ClO4）2 and flee PBT were each tested for their ability to inhibit the growth of two Gram（--） （Escherichia coil, Salmonella） and two Gram（＋） （Bacillus subtilis, Staphylococcus aureus） microorganisms. The complex showed good antibacterial activities against the microorganisms compared with free PBT and Cu（C104）2. The interaction between the complex and calf thymus DNA in aqueous solution was investigated using electronic spectroscopy, fluorescence spectroscopy, circular dichroic spectroscopy, and viscosity measurements. Results suggest that the complex could bind to DNA by an intercalative mode. In addition, the result of agarose gel electrophoresis showed that the complex can cleave the plasmid DNA by hydroxyl radicals and singlet oxygen-like species under the condition of physiological pH and room temperature.A new ternary complex [Cu（PBT）（Gly）（H2O）]ClO4 （PBT=2-（2＇-pyridyl）benzothiazole, and Gly=glycinate） has been synthesized and characterized by elemental analysis, molar conductivity, and IR methods. The complex, structurally characterized by single-crystal X-ray crystallography, shows a slightly distorted square-pyramidal coordination geometry in which two nitrogen atoms of PBT and the carboxylate oxygen atom O and the amino nitrogen atom N of Gly bind at the basal plane, a water molecule is coordinated at the apical position. The complex, Cu（ClO4）2 and flee PBT were each tested for their ability to inhibit the growth of two Gram（--） （Escherichia coil, Salmonella） and two Gram（＋） （Bacillus subtilis, Staphylococcus aureus） microorganisms. The complex showed good antibacterial activities against the microorganisms compared with free PBT and Cu（C104）2. The interaction between the complex and calf thymus DNA in aqueous solution was investigated using electronic spectroscopy, fluorescence spectroscopy, circular dichroic spectroscopy, and viscosity measurements. Results suggest that the complex could bind to DNA by an intercalative mode. In addition, the result of agarose gel electrophoresis showed that the complex can cleave the plasmid DNA by hydroxyl radicals and singlet oxygen-like species under the condition of physiological pH and room temperature.

关 键 词：copper（II） complex 2-（2＇-pyridyl）benzothiazole GLYCINATE DNA antibacterial activity 

分 类 号：O614.121[理学—无机化学] O614.33[理学—化学]