Synthesis and Photooxygenation of Furo[3,2-c]coumarin Derivatives as Antibacterial and DNA Intercalating Agent  

作　　者：Al-Sehemi,Abdullah G. EI-Gogary,Sameh R. 

机构地区：[1]Chemistry Department,Faculty of Science(Abha),King Khaled University,Kingdom of Saudia Arabia [2]Chemistry Department,Faculty of Science(Damietta),Mansoura University,Egypt

出　　处：《Chinese Journal of Chemistry》2012年第2期316-320,共5页中国化学（英文版）

摘　　要：Syntheses of 2,3-dimethyl-4H-furo[3,2-c]coumarin and 3-phenyl-4H-furo[3,2-c]coumarin as angular furocou- marins were carried out through Williamson reaction of 4-hydroxycoumarin with a-haloketones followed by cycli- zation. Photooxygenation of the synthesized furocoumarin derivatives was performed and the photoproducts were isolated and characterized. The affinity of 2,3-dimethyl-4H-furo[3,2-c]coumarin towards DNA and the antibacterial activity were evaluated and compared with 8-methoxypsoralen （8-MOP）.Syntheses of 2,3-dimethyl-4H-furo[3,2-c]coumarin and 3-phenyl-4H-furo[3,2-c]coumarin as angular furocou- marins were carried out through Williamson reaction of 4-hydroxycoumarin with a-haloketones followed by cycli- zation. Photooxygenation of the synthesized furocoumarin derivatives was performed and the photoproducts were isolated and characterized. The affinity of 2,3-dimethyl-4H-furo[3,2-c]coumarin towards DNA and the antibacterial activity were evaluated and compared with 8-methoxypsoralen （8-MOP）.

关 键 词：FUROCOUMARINS PSORALENS PHOTOOXYGENATION antibacterial activity and DNA 

分 类 号：O626.31[理学—有机化学] S859.796[理学—化学]