硫代二甘酸二乙酯的合成工艺  

Synthesis technology of diethyl thiodiglycolate

作　　者：廖喜慧[1] 刘于民[1] 沈玉堂[1] 王爱丽[1] 殷恒波[1] 

机构地区：[1]江苏大学化学化工学院,江苏镇江212013

出　　处：《化工进展》2012年第3期654-657,共4页Chemical Industry and Engineering Progress

基　　金：江苏省研究生创新基金项目(CX10B-259Z)

摘　　要：以氯乙酸乙酯和硫化钠(Na2S?3H2O)为原料,通过亲核取代反应制备硫代二甘酸二乙酯。重点研究了溶剂体系、物料比、反应温度等反应条件对反应速率及产物收率的影响。在溶剂环己烷用量250 mL,硫化钠(Na2S?3H2O)与氯乙酸乙酯的摩尔比为0.75∶1,反应温度81℃,反应时间4 h的反应条件下,硫代二甘酸二乙酯的收率达81.3%,纯度在99%以上。溶剂环己烷回收率80%以上。Diethyl thiodiglycolate was efficiently synthesized via the nucleophilic substitution of ethyl chloroacetate with Na2S＇3H20. The effects of molar ratio of Na2S-3H20 to ethyl chloroacetate, solvent and reaction temperature on the reaction rate and product yield were investigated. The maximum yield of diethyl thiodiglycolate reached 81.3% with a purity of 99% when the reaction was carried out with a molar ratio of Na2S＇3H20 to ethyl chloroacetate of 0.75 ： 1 in 250 mL cyclohexane under reflux at 81 ~C for 4 h. And the recovery rate of cyclohexane is more than 80%.

关 键 词：氯乙酸乙酯 硫化钠 硫代二甘酸二乙酯 合成工艺 

分 类 号：TQ218[化学工程—有机化工]