MMP-3和MMP-7在良恶性胸腔积液中的表达及意义  

The expressions and its significance of MMP-3 and MMP-7 in malignant pleural effusion

作　　者：刘敏[1] 

机构地区：[1]广西中医学院附属瑞康医院肿瘤二科,广西南宁530011

出　　处：《中国现代医生》2012年第7期127-128,共2页China Modern Doctor

摘　　要：目的探讨胸腔积液中基质金属蛋白酶-3(MMP-3)、基质金属蛋白酶-7(MMP-7)的表达意义,观察检测二者表达对胸腔积液性质的鉴别价值,以指导临床工作。方法选取我院诊治的89例恶性胸腔积液患者作为观察组,50例结核性胸腔积液(良性胸腔积液)作为对照组,应用酶联免疫吸附实验(ELISA)检测两组中MMP-3和MMP-7的表达。结果 MMP-3和MMP-7在观察组中的表达量明显高于对照组,观察组中MMP-3和MMP-7的表达与肿瘤的类型有关。相关分析显示观察组中MMP-3和MMP-7的表达呈正相关性。结论 MMP-3和MMP-7在恶性胸腔积液中的表达明显升高,在疾病进展中可能具有重要价值;MMP-3和MMP-7的表达对肿瘤类型的判断可能有一定价值。Objective To detect the expressions of MMP-3 and MMP-7, assess the clinical significance in pleural effusion for directing clinical work. Methods The study included 89 cases of malignant pleural effusion as observation group and 50 cases of benign pleural effusion as control group. We detected the expressions of MMP-3 and MMP-7 by ELISA. Results Comparisons of the malignant and benign pleural effusion showed that there were significant up-regulations of MMP-3 and MMP-7 in the observation group. The expressions of MMP-3 and MMP-7 were associated with types of neoplasm. Conclusion The expressions of MMP-3 and MMP-7 have significant up-regulation in the malignant pleura1 effusion. MMP-3 and MMP-7 may play an important role in the malignant pleural effusion. The combined examination of MMP-3 and MMP-7 may be helpful to judge the type of neoplasm.

关 键 词：基质金属蛋白酶-3 基质金属蛋白酶-7 胸腔积液 酶联免疫吸附实验 

分 类 号：R446.6[医药卫生—诊断学] R561.3[医药卫生—临床医学]