Genetic polymorphism of glutathione-S-transferase M1 and T1 in associated with carcinogenesis of hepatocellular carcinoma and nasopharyngeal carcinoma  

肝细胞癌、鼻咽癌患者谷胱甘肽硫转移酶M1和T1基因型分布(英文)

作　　者：Yiping Wei Xidai Long Ziguang Liu Yun Ma Zhuolin Deng 

机构地区：[1]Nursing College of Guangxi Medical University,Nanning 530021,China [2]Department of Pathology,YoujianNationality Medical College,Baise 533000,China [3]Department of Pathology,The First People Hospital of Zhaoqing,Zhaoqing 526000,China [4]Department of Pathology,Guangxi Medical University,Nanning 530021,China

出　　处：《The Chinese-German Journal of Clinical Oncology》2012年第3期138-141,共4页中德临床肿瘤学杂志（英文版）

基　　金：Supported by agrant from the National Natural Sciences Foundation of China (No. 39860032)

摘　　要：Objective:The aim of our study was to investigate the distribution of glutathione-S-transferase M1 (GSTM1) and T1 (GSTT1) gene polymorphism in hepatocellular carcinoma (HCC) and nasopharyngeal carcinoma (NPC) patients in a high risk area in Guangxi Zhuang Autonomous Region,China.Methods:It was a case-control study.The genotypes of GSTM1 and GSTT1 in 181 HCC and 126 NPC patients were compared with 641 matched control.The GSTM1 and GSTT1 genotypes were detected using conventional multiplex PCR method.Results:The frequency of GSTM1 null genotype in HCC,NPC and control groups were 65.2%,61.9% and 47.6% respectively,significant difference between these two cancer groups and control was observed (P < 0.01).The frequency of GSTT1 null genotype in HCC,NPC and control groups were 57.5%,62.7% and 43.1% respectively,significant difference between these two cancer groups and control was observed (P < 0.01).Conclusion:The distributions of GSTM1 and T1 genes are polymorphic in HCC and NPC patients in a high risk area in Guangxi,individuals with GSTM1-null or GSTT1-null would have an increasing risk of developing HCC and NPC,especially when combination with virus infection (HBV or EBV) and absorbed chemical toxin (AFB1 or cigarette).

关 键 词：hepatocellular carcinoma （HCC） nasopharyngeal carcinoma （NPC） glutathione-S-transferase M1 （GSTM1） and T1 （GSTT1） gene 

分 类 号：Q346.5[生物学—遗传学] X503.225[环境科学与工程—环境工程]