Application of three dimensional conformal radiation therapy combined with high-intensity focused ultrasound for prostate cancer  

三维适形放疗联合高强度聚焦超声治疗前列腺癌临床疗效观察(英文)

作　　者：Hui Yao Jinlan Gong Li Li Xiaofeng Wu Jianjun Yu 

机构地区：[1]Department of Radiotherapy,Shanghai Shidong Hospital,Shanghai 200438,China

出　　处：《The Chinese-German Journal of Clinical Oncology》2012年第3期164-167,共4页中德临床肿瘤学杂志（英文版）

基　　金：Supported by agrant from the Network Researches of Tumor Precise Radiation Therapy of Ministry of Health of China(No.WKJ2005-3-006)

摘　　要：Objective:Prostate cancer is a form of cancer that develops in the prostate,a gland in the male reproductive system.Prostate cancer tends to develop in men over the age of fifty;it is one of the most prevalent types of cancer in men.This article introduced a new method of prostate cancer treatment with the combination of three dimensional conformal radiation therapy (3D-CRT) and high-intensity focused ultrasound (HIFU),its efficacy was evaluated.Methods:From January 2004 to December 2009,95 patients were diagnosed with prostate cancer,among them,48 patients were received combined therapy with total irradiation of TD 60 Gy/30 Fx and 5 fractions of HIFU treatment,while 47 patients were received with pure 3D-CRT with total irradiation of TD (66-72) Gy/(33-36) Fx.Various indicators were evaluated,such as the local control rate and distant metastasis rate,the changes in blood PSA and fPSA,changes in T-lymphocyte subsets and NK cells,as well as acute adverse reaction of normal tissue.Results:The local response rate difference between the two groups had statistical significance (P < 0.05);the changes in blood PSA and fPSA were significant (P < 0.05);CD3+,CD4+,CD8+,CD4+/CD8+ and NK cells of the combined group increased obviously (P < 0.01),while the latter group had no increase (P > 0.05);the combined group had lower blood cells reduction and II-level acute adverse reaction of rectum,bladder and caput humeri than the pure group,but the II-level acute adverse reaction of urogenital canal in the combined group was higher (P < 0.05).Conclusion:The combined therapy with 3D-CRT and HIFU is a good way for the treatment of aged-related prostate cancer.It can ease the symptoms,control the disease and lengthen the survival time.

关 键 词：prostate cancer three dimensional conformal radiotherapy （3D-CRT） high-intensity focused ultrasound （HIFU） 

分 类 号：Q78[生物学—分子生物学] TB559[理学—物理]