系膜增生性肾病与TGF-β、MMPs、NF-KB和PDGF关系的研究进展  

Review on the Relationship among Mesangial Proliferation Nephropathy and TGF-β,MMPs,NF-KB and PDGF

作　　者：赵宝玲[1] 任现志[2] 

机构地区：[1]南京中医药大学,南京210029 [2]南京中医药大学附属江苏省中医院

出　　处：《浙江中医药大学学报》2012年第1期113-116,共4页Journal of Zhejiang Chinese Medical University

基　　金：国家自然基金(81173298)~~

摘　　要：系膜细胞的增生是多种原发性和继发性肾小球疾病的主要病理特点,系膜细胞增殖和细胞外基质沉积是导致肾小球硬化的重要因素。系膜增生性肾炎(MsPGN)是我国原发性肾小球疾病中常见的病理类型,约占我国肾穿刺病人的20%～25%。因此,抑制系膜细胞增生及细胞外基质的沉积成为治疗此类疾病的关键。本篇就系膜增生性肾病与TGF-β的表达、基质金属蛋白酶类(ma-trix metalloproteinases,MMPs)的活化、NF-KB的活化和PDGF的旁分泌或自分泌之间的关系加以论述。Mesangial cell proliferation is cardinal pathology characteristic of various primary glomerulopathy and secondary glomerulopathy,mesangial cell proliferation and extracellular matrix deposit are major factors of induced glomerulosclerosis.Mesangial proliferative glomerulonephritis is of common pathologic type,accounting for approximately 20%~25% of precutaneous needle renal biopsy in our country.Therefore,inhibiting mesangial cell proliferation and extracellular matrix deposit is key to treat this sort of disease.This paper chiefly elaborates connections which are mesangial cell proliferation nephropathy and TGF-β expression,MMPs activation,NF-KB activation,PDGF paracrine,autocrine.

关 键 词：系膜细胞增殖 转化生长因字β 基质金属蛋白酶类 核转录因子 血小板源性生长因子 

分 类 号：R692[医药卫生—泌尿科学]