脊髓损伤治疗中的细胞移植策略及预处理研究进展  

The Research Progress of Cell Transplantation for Treatment of Spinal Cord injury and Preconditioning of Stem Cells

作　　者：孙崇毅[1] 刘庆鹏[1] 姚猛[1] 韩竹[1] 肖艳秋[1] 乔久涛[1] 

机构地区：[1]哈尔滨医科大学附属二院骨科,黑龙江哈尔滨150086

出　　处：《现代生物医学进展》2012年第1期171-174,共4页Progress in Modern Biomedicine

基　　金：黑龙江省自然科学基金(D200671)

摘　　要：急性脊髓损伤是骨科常见的严重疾患,伤后神经功能恢复及重建是近年来研究的热点,其中细胞移植的研究得到广泛的关注并取得较大的研究进展。本文介绍了细胞移植治疗脊髓损伤治疗的研究现状,其中对移植细胞的来源,移植的时机,移植的途径以及细胞移植存活的问题及应对策略做了重点阐述。同时对增加移植细胞存活率的预处理方法做了简要综述。Acute spinal cord injury（ASCI） is a serious and common disease of the orthopedics,After injury neurological recovery and reconstruction is the hot spot of the research in recent years,and the research of cell transplantation get wide attention and make great progress.This paper introduces the present research status of the cell transplantation for the treatment of spinal cord injury.Among them,the source of the cell transplantation,the timing of the cell transplantation,the approach of the cell transplantation,the problem of survival after cell transplantation and the coping strategy are maked a detailed description.At the same time we make a simple review for the preconditioning method which increase the survival rate of the cell transplantation.Many new therapeutic measures are still in the experimental stage at present,but the transform from the successful empirical study of neuroprotection and neurotization to clinical application by some new skills will come soon.

关 键 词：细胞移植 脊髓损伤 神经干细胞 预处理 

分 类 号：R651.2[医药卫生—外科学] R681.5[医药卫生—临床医学]