聚乙二醇-聚乳酸嵌段共聚物纳米粒的研究进展  

Study Progress of Polyethylene Glycol-Polylactic Acid Block Copolymer Nanoparticles

作　　者：曾昭武[1,2] 肖人钟[2] 王小丽[1] 刘星言[1] 

机构地区：[1]广东医学院,广东东莞523808 [2]杭州师范大学,浙江杭州311121

出　　处：《现代生物医学进展》2012年第1期179-182,191,共5页Progress in Modern Biomedicine

基　　金：国家自然科学青年基金项目(81001647);浙江省科技厅资助项目(2009C33005);中国博士后科学基金面上项目(20100471757)

摘　　要：聚乙二醇-聚乳酸嵌段共聚物(PEG-PLA)及其端基衍生物纳米粒可以增强载药量、降低突释效应、提高药物在血液中的循环时间、提高生物利用度,并且其粒径更小,能以被动靶向的方式聚集于炎症或靶向部位。本文综述了PEG-PLA嵌段共聚物纳米粒的最新进展,包括PEG-PLA的合成、纳米粒的制备、释药特性及在药物制剂中的应用。Polyethylene glycol-polylactic acid（PEG-PLA） block copolymer and its end-group derivative nanoparticles may en-hance the drug-loading rate,reduce the burst effect,extend drug circulation time in blood and improve bioavailability.Moreover,because of their smaller particle size and modified surface,these nanoparticles may accumulate in inflammation or target locations by passive tar-geting to enhance drug efficacy and reduce toxicity.Recent progress in PEG-PLA block copolymer nanoparticles,including the synthesis of PEG-PLA and the preparation of PEG-PLA nanoparticles,the drug release characteristics and their application in pharmaceutical preparations were introduced in this review.

关 键 词：聚乙二醇-聚乳酸 纳米粒 药物传递系统 

分 类 号：R944.1[医药卫生—药剂学]