糖尿病合并抑郁患者临床干预研究  

A clinical intervention on the diabetes patients with complicating depression

作　　者：屠云[1,2] 徐春兰[1,2] 华飞[1,2] 

机构地区：[1]苏州大学附属三院 [2]常州第一人民医院,213003

出　　处：《护理实践与研究》2012年第5期4-6,共3页Nursing Practice and Research

基　　金：江苏省常州市卫生局指导性科技项目;苏州大学附属三院科研基金资助项目(WZ200609)

摘　　要：目的:研究心理行为以及药物联合干预手段对糖尿病合并抑郁患者抑郁指数的影响。方法:采用Zung自评抑郁量表(SDS)对2007年1～7月在我院内分泌科住院的243例糖尿病患者进行抑郁筛查评定,根据SDS得分计算抑郁指数,抑郁指数≥0.5者为抑郁。将获得的110例糖尿病合并抑郁患者随机分为试验组和对照组各55例。试验组给予心理行为以及药物联合干预,对照组给予常规治疗。比较两组患者在研究基线、治疗后6,12,24,36个月抑郁指数的差别,同时比较两组患者治疗后6,12,24,36个月后抑郁指数与基线的变化值。采用重复测量资料方差分析的方法,分析时间因素与干预的交互作用。结果:经均衡性检验,人口学特征、临床因素两组间分布无统计学意义(P>0.05)。在治疗6,12,24及36个月后,试验组抑郁指数明显低于对照组,差异均有统计学意义(P<0.01)。与基线相比,在不同观察时点上,两组患者的抑郁指数均有下降,但试验组的下降幅度均比对照组大,差异均有统计学意义(P<0.01)。其中试验组36个月后抑郁指数平均下降25.4%(0.15/0.59);而对照组平均下降15.3%(0.09/0.59)。重复测量资料方差分析结果提示:时间因素与干预因素间有协同作用(P<0.01)。在干预6个月后,抑郁指数下降最明显,随着观察时点的推移,抑郁指数的下降幅度逐渐减缓。结论:心理行为以及药物联合干预能明显降低糖尿病合并抑郁患者的抑郁指数。早期干预疗效最好。to study on the effectiveness of the depression index of diabetes patients suffering from depression after carrying out the comprehensive intervention of psychological and medication treatment. Methods ：243 hospitalized patients suffering from diabetes were evaluated the depression index by self - rating depression scale （SDS）. The subjects whose depression index≥0.5 were defined as depression cases. The 110 diabetes patients with complication of depression were randomly assigned into intervention group （55 cases） and control group （55 cases）. Intervention group were given the psychological and medication treatment,and the control group were only given the normal treatment. The difference for the depression index between two groups at baseline, 6, 12, 24 and 36 months followed time were compared using t - test, and the difference to the baseline of two groups for the depression index at 6, 12, 24 and 36 months followed time were also estimated and compared by t - test. Repeated measurement data ANOVA was performed to explore the interaction effect of the intervention and time factors. Results ： No significant difference for the demographic and clinical characteristics were found between the intervention and control groups （P 〉 0.05）. The depression index of the intervention group were all significantly lower than control at 6, 12, 24, and 36 months followed time （ P 〈 0.01 ）. Compared to the baseline, the two groups＇ depression index were all significantly decreased at different followed times, furthermore, the decreasing degree for the intervention group were significantly higher than the control （P 〈 0.01 ）. Totally, about 25.4 % （0.15/0.59） and 15. 3% （0.09/0.59） depression index decrease were found in the intervention and control group, respectively. Repeated measurement data ANOVA showed that there was a significant interaction effect between intervention and time factors （ P 〈 0.01 ）. The largest depression index decrease was seen at 6 months followed time

关 键 词：糖尿病 抑郁 心理行为干预 

分 类 号：R473.5[医药卫生—护理学]