男性冠心病患者血浆睾酮与超敏C反应蛋白、白介素-6及同型半胱氨酸的关系  

Relationship between testosterone and high-sensitivity C-reactive protein,interleukin-6,homocysteine in male patients with coronary heart disease

作　　者：王琦[1] 吴赛珠[1] 张帆[1] 刘公理[1] 阮云军[1] 赖文岩[1] 

机构地区：[1]南方医科大学南方医院心血管内科,广东广州510515

出　　处：《中国老年学杂志》2012年第5期889-891,共3页Chinese Journal of Gerontology

基　　金：国家"973"项目子课题(No.2007CB507400)

摘　　要：目的观察男性冠心病患者血浆睾酮水平与血浆中超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)、同型半胱氨酸(Hcy)水平的关系。方法将95例患者分为冠心病组(50例)与对照组(45例),分别检测两组睾酮、hs-CRP、IL-6、Hcy、总胆固醇(TC)、甘油三酯(TG)水平,并收集两组病例年龄、吸烟史、高血压史、体质指数等基本临床信息。结果冠心病组与对照组在年龄、高血压史、吸烟史、体质指数、血脂水平比较差异均无统计学意义(P>0.05)。冠心病组与对照组相比,血浆睾酮显著低于对照组,hs-CRP、IL-6、Hcy显著上升(P<0.05)。Pearson直线相关分析表明,冠心病组的血浆睾酮水平与hs-CRP(r=-0.760,P<0.05)、IL-6(r=-0.625,P<0.05)、Hcy(r=-0.529,P<0.05)水平呈显著负相关。结论冠心病患者血浆睾酮水平降低,但Hcy及炎性反应水平升高;睾酮的水平与炎性反应水平和Hcy水平呈负相关。Objective To investigate the relationship of testosterone and high-sensitivity C-reactive protein （hs-CRP）, interleukin- 6 （1L-6） and homocysteine （Hcy） in old male patients with coronary heart disease （CHD）. Methods 50 CHD patients and 45 control subjects were selected from nanfang hospital. Levels of hs-CRP, IL-6, Hcy, total cholesterol （TC）, triglyceride （TG） and testosterone were determined. Basic clinical data including age, smoking, hypertension and body mass index （BMI） were evaluated. Results Compared with control subjects, hs-CRP, IL-6, homocysteine were elevated and testosterone was decreased （P 〈 0. 05 ） in CHD group. There was no signif- icant difference in age, BMI, TC and TG between two groups. There was negative correlation between CRP, IL-6, homocysteine and testos- terone. Conclusions Male patients with CHD have lower level of testosterone and decreased testosterone, which appears to be associated with greater inflammation reaction in vascular and higher level of homocysteine.

关 键 词：冠状动脉粥样硬化性心脏病 睾酮 超敏C反应蛋白 白介素6 同型半胱氨酸 

分 类 号：R541[医药卫生—心血管疾病]