乙型肝炎与载脂蛋白基因多态性相关性研究  

Investigation of the relationship between apolipoprotein gene polymorphism and hepatitis B virus infection in China

作　　者：尹志农[1] 周新[2] 鄢盛恺[3] 王俊文[1] 孟庆玲[4] 刘薇[5] 

机构地区：[1]北京市垂杨柳医院暨北京微创医院实验中心,100022 [2]武汉大学中南医院基因诊断中心 [3]卫生部中日友好医院检验科 [4]中国疾病预防控制中心病毒病预防控制所肝炎室 [5]河北医科大学

出　　处：《中华实验和临床病毒学杂志》2012年第1期28-30,共3页Chinese Journal of Experimental and Clinical Virology

摘　　要：目的探讨ApoAI-75Mspl、ApoB—Msp1、ApoCllI—Sst1、LRP5、ApoE基因多态性与乙型肝炎血清标志物不同模式之间的内在相关性。方法将乙型肝炎血清标志物不同模式分为9组，每组80人，共720人份，采用SnaPshot法检测上述基因的多态性，最后用测序法佐证检测结果的准确性。结果ApoAI-75Msp1、ApoE基因在乙型肝炎血清标志物不同模式之间差异有统计学意义（P〈0．05），ApoCIII-Sst1、ApoB．Msp1、LRP5基因则差异无统计学意义（P〉0．05）。结论ApoAI-75Msp1、ApoE基因多态性与乙型肝炎血清标志物不同模式有相关性，ApoCIII-Sstl、ApoB—Msp1、LRP5与乙型肝炎血清标志物不同模式无相关性。Objective To explore the gene polymorphisms of ApoAI-75 Mspl ,ApoB Mspl ,ApoCIlI Sstl, LRPS, and ApoE genotypes in two pairs of semi different modes of hepatitis B for HBV markers. Methods The patients are divided into 9 groups. There were a total of 720 cases, 80 patients in each group, The patients was carried out by SnaPshot method （single-base multilocus micro-sequencing）, and different genotypes of each locus were conducted by the method of sequencing in order to support the final evidence of the accuracy of test results. Results There was association between gene polymorphisms of ApoAI-75Mspl and ApoE and different modes of two pairs of semi-hepatitis B （ P 〈 0.05 ） , while there wasn＇t any association between gene polymorphisms of ApoB-Mspl, ApoCIII-Sstl, LRP5 and different modes of two pairs of semi-hepatitis B （P 〉 0.05）. Conclusion The gene polymorphism of ApoAI-75Mspl and ApoE was associated with the different modes of HBV markers.

关 键 词：载脂蛋白类 基因 多态现象(遗传学) 肝炎 乙型 

分 类 号：R512.62[医药卫生—内科学]