大黄素/Mg-Al-LDHs纳米杂化物的制备及缓释性能研究  

Synthesis and Release Behavior of Emodin Intercalated Mg-Al Hydrotalcite-Like Compounds

作　　者：戴肖南[1] 王其鹏[1] 

机构地区：[1]山东轻工业学院化学与制药工程学院,济南250353

出　　处：《无机化学学报》2012年第3期560-564,共5页Chinese Journal of Inorganic Chemistry

基　　金：山东省中青年科学家科研奖励基金(No.2007BS04026)资助项目

摘　　要：以Mg-Al型层状双金属氢氧化物(Mg-Al-LDHs)为载体,将大黄素分子通过二次组装法成功插入其层间,得到大黄素/Mg-Al-LDHs纳米杂化物。XRD结果显示,Mg-Al-LDHs粒子层间距由0.48 nm增大到3.35 nm。差热曲线(DTA曲线)分析结果表明,该纳米杂化物分子中大黄素的分解温度比纯大黄素的分解温度高50℃。分别在pH 4.8和pH 7.5的缓冲溶液中测定了大黄素/LDHs的缓释性能,结果表明大黄素/LDHs的药品释放速率明显低于二者的物理混合物,并探讨了释放机理。In this paper,emodins were successfully intercalated into the gallery of Mg-Al hydrotalcite-like compounds（LDHs）,to obtain nanohybrids.The results of X-ray powder diffraction（XRD） showed that the interlayer distance of Mg-Al-LDHs was increased from 0.48 nm to 3.35 nm.The DTA results suggested that the discomposition temperature of the nanohybrids increased by 50 ℃ in comparison with that of emodin.The determination results of the drug release indicated that the drug release rate from the emodin/LDHs nanohybrids was much slower than that from the corresponding physical mixture at either pH 4.8 or pH 7.5.The release mechanism was discussed.

关 键 词：层状双金属氢氧化物(LDHs) 大黄素 插层 缓释 

分 类 号：O648.1[理学—物理化学]