特发性全身强直-阵挛发作患儿智商及影响因素  

Study of intelligence quotient and influencing factors on the children with idiopathic generalized tonic-clonic seizure

作　　者：黄会芝 胡晓峰[4] 温晓红 唐章龙 李晓燕 金岚 吴晓燕 储微 唐久来 

机构地区：[1]安徽医科大学第三附属医院儿科,合肥230000 [2]第一附属医院小儿神经康复中心 [3]安徽省宣城市人民医院神经内科 [4]安徽省立医院放射科

出　　处：《中华行为医学与脑科学杂志》2012年第2期142-145,共4页Chinese Journal of Behavioral Medicine and Brain Science

摘　　要：目的研究特发性全身强直．阵挛发作（GTCS）患儿智商（IQ）及影响因素。方法选择皖南山区20个GTCS家系中所有28名年龄在9—16岁GTCS患儿作为癫痫组，与年龄、性别可比的同胞（对照组1）及同村健康儿童（对照组2）相比较，研究3组儿童的IQ及GTCS患儿智商的影响因素，所有数据用SPSS12．0进行分析。P〈0．05为有统计学意义。结果①癫痫组儿童的平均总智商[（85．64±20．57）分]比对照组1[（103．39±11．17）分]及对照组2[（106．17±11．67）分]低。除填图与图片排列外，癫痫组的所有其他分测验得分均低于两对照组，差异具有统计学意义（P〈0．01）。②对照组1与对照组2之间的IQ及各分测验得分差异无统计学意义。③GTCS患儿IQ与父亲受教育程度（r=0．453，P〈0．01）、癫痫发病年龄（r=0．506，P〈0．01）、癫痫发作病程（即自第1次癫痫发作至最后1次发作的时间阶段，r=-0．533，P〈0．01）、癫痫发作频率（r=-0．708，P〈O．01）、癫痫持续状态（r=-0．732，P〈O．01）显著相关。结论特发性GTCS患儿IQ明显低于同胞及一般健康儿童；影响GTCS患儿IQ的癫痫相关变量有癫痫发作病程、癫痫持续状态、癫痫发病年龄、总的癫痫发作次数、癫痫发作频率。Objective To study the intelligence quotient（IQ） profile of the children with idiopathic gen- eralized tonic-clonic seizure （GTCS） and the factors influencing IQ of them. Methods All 28 children with GTCS were selected who were aged 9 - 16 years in 20 GTCS families in a mountain area of the south of Anhui Province, all available healthy siblings of the children included in the epilepsy group, did not have epilepsy, and were nearest in age to the children with GTCS （control group 1 ） ,and thirty children aged 9 -16 years old who had lived in the same village （ control group 2） entered into our study. The IQ was studied of the three groups of children and the factors influencing IQ of children with GTCS at the same time. The data were input SPSS12.0 and analyzed. Re- suits The IQ of children with GTCS（ 85.64 ± 20.57 ） was lower than that control group 1 （ 103.39 ± 11.17 ） and the control group 2 （ 106.17 ± 11.67 ）. The difference between children with GTCS and the two control groups were significant for almost all the suhtest quotients except completion of drawing and picture arrangement. No significant differences were found between the control group 1 and the control group 2 on the IQ and the subtest quotients. IQ scores of children with GTCS showed significant linear correlation with father＇s education（ r = 0. 453, P 〈 0.01 ） , age at onset of epilepsy（ r=O. 506, P〈0.01 ） ,duration of seizure disorder（ r= -0. 533, P〈0.01 ） ,status epilepticus（ r = - 0. 732, P 〈 0.01 ） , total number of seizures （ r = - 0. 761, P 〈 0.01 ） and seizure frequency （ r = - 0. 708, P 〈 0.01 ）. Conclusion The IQ scores of the children with idiopathic GTCS are lower significantly than general children population. Epilepsy-related variables affecting IQ scores of the children with idiopathic GTCS are duration of seizure disorder, status epilepticus, age at onset of epilepsy, total number of seizures, seizure frequency.

关 键 词：特发性 全身强直-阵挛发作 总智商 言语智商 操作智商 

分 类 号：R971.6[医药卫生—药品]