二硫代二丙酰胺衍生物的合成及其抑菌性能与防污性能  

A Study on the Synthesis of Dithiodipropionamide Derivatives and Their Bacteriostatic and Antifouling Properties

作　　者：苗展展 姜晓辉[1] 于良民[1] 

机构地区：[1]中国海洋大学海洋化学理论与工程技术教育部重点实验室,山东青岛266100

出　　处：《精细化工》2012年第3期299-302,共4页Fine Chemicals

基　　金：国家高技术研究发展计划(863计划)资助(2010AA09Z203和2010AA065104);海洋公益性行业科研专项经费资助(201005028-2);青岛市科技支撑计划资助(11-2-3-34-nsh);国家海洋局海洋生态环境科学与工程重点实验室开放基金资助(MESE-2010-07)~~

摘　　要：以丙烯酸甲酯为原料,经过二硫代反应、酯的氨解反应,得到N,N'-二丁氧基丙基二硫代二丙酰胺(BPD)、N,N'-二甲氧基丙基二硫代二丙酰胺(MPD)、N,N'-二正辛基二硫代二丙酰胺(OLPD)3种二硫代二丙酰胺衍生物,利用红外光谱和核磁共振波谱表征其结构。3种化合物分别对大肠杆菌和金黄色葡萄球菌进行抑菌实验,结果表明,3种受试化合物对大肠杆菌、金黄色葡萄球菌均具有较好的抑制作用,抑制效果BPD≈MPD>OLPD。BPD对两种菌株的MIC值可达0.062 5 g/L。将所得化合物制备成涂料,通过海上挂板实验研究其防污性能;海上挂板结果表明,3种化合物都具有较好的防污作用,防污效果BPD>MPD>OLPD。Three dithiodipropionamide derivatives, N, N＇-dimethoxypropyl-dithiodip-ropionamide （MPD）, N, N＇-dibutoxypropyl-dithiodipropionamide （BPD）, N, N＇-dinoctyl-dithiodipropionamide （0LPD） were synthesized from methyl acrylate in the .aqueous phase and detected by infrared spectrometer and NMR spectrometer. The bioassay results show that all the three compounds possessed good antibacterial activity, with MIC value of BPD to Escherichia Coli and Staphylococcus aureus reaching 0. 062 5 g/L. Then the compounds were applied in the manufacture of antifouling paintings. The study of their antifouling properties by submerging in the ocean shows that they all have good antifouling qualities. BPD exhibited the best antifouling property.

关 键 词：二硫代二丙酰胺 抑菌 防污 海洋挂板 精细化工中间体 

分 类 号：TQ21[化学工程—有机化工] O622[理学—有机化学]