响应面法优化丹皮酚巴布剂基质处方研究  

Optimization of matrix recipe of paeonol cataplasm with response surface method

作　　者：翟科峰[1,2] 段红[2] 曹稳根[2] 高贵珍[2] 

机构地区：[1]安徽宿州学院特色种植业苗种生产工程技术研究中心,安徽234000 [2]宿州学院化学与生命科学学院

出　　处：《北京中医药大学学报》2012年第2期125-129,共5页Journal of Beijing University of Traditional Chinese Medicine

基　　金：安徽省教育厅自然科学研究资助项目(No.KJ2011B182);宿州学院特色种植业苗种生产工程技术研究中心开放课题资助项目(No.2011YKF19);宿州学院产学研合作资助项目(No.2011cxy01);安徽省高等学校省级优秀人才基金资助项目(No.2012SQRL200)

摘　　要：目的优选丹皮酚巴布剂最佳基质的配比,制备性能优良的巴布剂。方法采用响应面设计,以基质均匀性、延展性、膜残留性、皮肤追随性、黏度、剥离强度为综合指标,以配方原料为因素,对巴布剂基质组成比例进行优化。结果通过对析因实验,爬坡实验和Box-Behnken实验数据进行分析,优选出最佳配方比为乙二胺四乙酸(EDTA)∶甘羟铝∶酒石酸∶K-90∶甘油∶XL-10∶NP-800=0.20∶0.20∶0.10∶1.00∶28.62∶1.95∶5.88。结论所得配方基质较优,制备出丹皮酚巴布剂符合药剂学要求。Objective To optimize the best proportion of matrix recipe of paeonol cataplasm to prepare good eataplasm. Methods The composition proportion of cataplasm matrix was optimized taking matrix uniformity, ductility, membrane rescue, skin following, viscosity and peeling strength as comprehensive indexes and raw materials of recipe as factors by using response surface design. Results Through the analysis on the data of factorial experiment, climbing experiment and Box-Behnken experiment, the best recipe proportion was as follows ： EDTA： dibydroxyaluminii Aminoacetate ： tartaric acid ： K-90 ： glycerin： XL-10：NP-800 was 0.20： 0.20： 0. 10： 1.00： 28.62： 1.95： 5.88. Conclusion The matrix recipe obtained in the experiment was better, and prepared paeonol eataplasm accorded with the requirements of pharmaceutics.

关 键 词：丹皮酚 巴布剂 基质 响应面实验 

分 类 号：R283[医药卫生—中药学]