预温针灸与温针灸大鼠“神门”穴对缺血性心律失常损伤的影响  

Influences of pre-warming acu-moxibustion and warm acu-moxibustion in Shenmen(HT7) on ischemic arrhythmia in rats

作　　者：杨佳[1] 嵇波[1] 张露芬[1] 赵百孝[1] 王亚萍[1] 王晔[1] 时丽媛[1] 赵文斌[1] 

机构地区：[1]北京中医药大学针灸推拿学院,北京100029

出　　处：《北京中医药大学学报》2012年第2期141-144,共4页Journal of Beijing University of Traditional Chinese Medicine

基　　金：国家重点基础研究发展计划(973计划)资助项目(No.2009CB522906);北京中医药大学大学生招标课题资助项目(No.0100518)

摘　　要：目的对比观察预温针灸和温针灸对缺血性心律失常大鼠心电图的改变以及血清中肌酸激酶(CK)、乳酸脱氢酶(LDH)的影响。方法将Wistar大鼠随机分为4组,包括正常组、模型组、预温针灸组和温针灸组,每组9只。舌下注射氯化钡制作缺血性心律失常模型,采用心电图观测预温针灸和温针灸"神门"穴对心率、QRS波和复率时间的影响,生化法检测血清中CK、LDH活性的影响。结果温针灸和预温针灸可改善缺血性心律失常大鼠变异的QRS波形;温针灸可以使缺血性心律失常大鼠心率降低,复率时间缩短,使血清中CK和LDH活性显著降低。结论温针灸在改善缺血性心律失常同时,可以保护心肌损伤,而预温针灸对此病效应不稳定。2种治疗方法效应差异机理有待进一步研究。Objective To compare and observe the influences of pre-warming acu-moxibustion and warm acu-moxibustion in Shenmen （HT7） on the activities of serum creatine kinase （CK） and lactate dehydrogenase （LDH） in rats with ischemia arrhythmia. Methods Wistar rats were randomly divided into normal group, model group, pre-warming acu-moxibustion group and warm acu-moxibustion group （each = 9）. The model of ischemia arrhythmia was established by sublingual injection of barium chloride. The influences of pre-warming acu-moxibustion and warm acu-moxibustion in HT7 on heart rate, QRS wave and recovery time of heart rate were observed by ECG, and those on the activities of serum CK and LDH were detected by using biochemistry assay. Results Pre-warming acu-moxibustion and warm acu-moxibustion corrected variant QRS wave, and warm acu-moxibustion decreased heart rate, shortened recovery time of heart rate and reduced the activities of serum CK and LDH in rats with ischemia arrhythmia. Conclusion Warm acu-moxibustion can prevent myocardial injury at the same time of relieving ischemia arrhythmia, but pre-warming acu-moxibustion is not stable. It is necessary to study further on the mechanism of difference in curative effect of two therapies.

关 键 词：预温针灸 温针灸 神门 缺血性心律失常 大鼠 

分 类 号：R245[医药卫生—针灸推拿学]