八乙基卟啉的合成研究进展  

Progress in synthesis of octaethylporphyrin

作　　者：汪进[1] 魏月贞[2] 张志谦[2] 薛玉[2] 

机构地区：[1]哈尔滨工业大学分析测试中心,哈尔滨150001 [2]哈尔滨工业大学应用化学系,哈尔滨150001

出　　处：《化学试剂》2000年第1期30-33,共4页Chemical Reagents

摘　　要：八乙基卟啉以吡咯为合成前体 ,主要有 2种基本合成路线 ,一是以 5-甲基 -3 ,4 -二乙基 -2 -乙氧羰基吡咯为合成前体 ,由吡咯 α位甲基的碳原子构成卟啉的次甲基桥 ,另一路线是以 3 ,4 -二乙基吡咯为合成前体经与甲醛缩合 ,并以甲醛碳原子构成卟啉的次甲基桥 ,本文详细地介绍了这些中间体和八乙基卟啉的合成 ,并对比较典型的There are two fundamental synthetic routes for octaethylporphyrin from pyrroles.In the first route,3,4 diethyl 5 methyl 2 ethoxycarbonylpyrrole is used as the precursor and the pyrrolic α methyl carbon turned into the methine bridge of porphyrin.In the second route,the methine bridge composed of the formaldehyde carbon atom was prepared in acid catalysis by condensation of 3,4 diethylpyrrole with formaldhyde.In this paper synthesis of the intermediates and porphyrin are introduced in detail,and six representative total synthetic methods for octaethylporphyrin are reviewed.

关 键 词：八乙基卟啉 全合成 吡咯环 合成路线 

分 类 号：O626.13[理学—有机化学]