盐酸维拉帕米药物树脂复合物的制备及其体外释药动力学  

Preparation of Verapamil Hydrochloride Resin Complexes and Their Drug Release Kinetics in vitro

作　　者：李振华[1] 皮洪琼[1] 何炳林[1] 

机构地区：[1]吸附分离功能高分子材料国家重点实验室

出　　处：《应用化学》2000年第1期1-5,共5页Chinese Journal of Applied Chemistry

基　　金：国家教委博士点基金! (980 0 550 4 );南开大学吸附分离功能高分子材料国家重点实验室资助

摘　　要：研究了盐酸维拉帕米 (VH)与强酸性阳离子交换树脂 (0 0 1× 7)的交换反应动力学及其药物树脂复合物在去离子水、0 5mol/L、1 0mol/L、2 0mol/LNaCl和 0 5mol/LHCl以及 0 5mol/LKCl溶液中的释药动力学 .交换动力学结果表明 ,随温度的升高 ,药物与树脂的交换率增加 ,交换反应达平衡时 ,VH的平衡常数为 0 0 5 2 7;VH与 0 0 1× 7树脂的交换过程属于粒扩散过程控制 .体外释药动力学研究表明 ,VH药物树脂复合物在去离子水中不释放药物 ,但其释药速率随介质中离子强度的增加而增加 ;其释放动力学过程可用Viswanathan方程来描述 ,并且VH在上述释放介质中的释放属于粒扩散过程控制 ,粒扩散系数随释放介质中离子强度的增加而增加 .The exchange reaction kinetics of verapamil hydrochloride(VH) with the strongly acidic cation exchange resin (001×7) and the release property of VH from the drug resin complexes in deionic water, 0 5～2 0 mol/L NaCl and 0 5 mol/L HCl as well as 0 5 mol/L KCl solutions have been studied. It is found that the exchange rate increases with increase of temperature. The equilibrium constant of VH was 0 0527(298 K). The exchange reaction of VH with 001×7 was found to be controlled by particle diffusion process. The study of drug release in vitro showed that no VH release was found from drug resin complexes in deionic water medium. The release rate increased with increase of ionic strength of the release medium. The release of VH from drug resin complexes could be effectively controlled by the strongly acidic cation exchange resin (001×7). The diffusion of VH within the resin particles was controlled by a particle diffusion process according to Viswanathan′s equation. The diffusion coefficients increased with the increase of the ionic strength of the releasing media.

关 键 词：盐酸维拉帕米 释药动力学 ORCRS 药物树脂 

分 类 号：R944.9[医药卫生—药剂学] R972[医药卫生—药学]