病毒性心肌炎患儿血清一氧化氮与微量元素锌的变化及临床意义  

Changes and clinical significances of nitric oxide and zinc in serum of children with viral myocarditis

作　　者：韩燕燕[1] 聂抒[1] 朴金花[1] 郑广力[2] 

机构地区：[1]吉林大学第一医院儿科,吉林长春130021 [2]吉林省长春市儿童医院

出　　处：《中国妇幼保健》2012年第8期1168-1169,共2页Maternal and Child Health Care of China

摘　　要：目的:探讨一氧化氮(NO)和微量元素锌(Zn)在病毒性心肌炎(VMC)中的作用及临床意义。方法:采用比色法、原子吸收分光光度分析法测定42例VMC患儿及23例正常健康儿的血清NO、Zn水平。结果:急性期VMC患儿血清NO含量为(61.35±18.92)μmol/L,较对照组(23.81±5.37)μmol/L、恢复期(33.95±8.86)μmol/L患儿明显升高(P<0.01);而急性期VMC患儿血清Zn浓度为(76.81±11.05)μmol/L,较对照组(116.28±11.76)μmol/L、恢复期(89.75±9.90)μmol/L患儿降低(P<0.01);VMC患儿急性期NO与Zn呈高度负相关(P<0.05)。结论:血清NO、Zn含量变化与VMC的发生发展有关。Objective： To explore the effects and clinical signifieanees of nitric oxide and zinc in children with viral myocarditis. Methods： Colorimetry and atomic absorption spectrophotometry were used to detect the serum levels of nitric oxide and zinc in 42 children with viral myoearditis and 23 normal healthy children. Results： The serum level of nitric oxide in viral myoearditis group during acute phase was （61.35 ± 18.92） μmol/L, which was significantly higher than those in control group [ （23. 81±5.37） μmol/L] and viral myoearditis group during recovery phase [ （33.95 ±8. 86） μmol/L] （P 〈0. 01） . The serum level of zinc in viral myoearditis group during acute phase was （76. 81 ± 11.05） μmol/L, which was significantly lower than those in control group [ （ 116. 28 ± 11.76） μmoL/L] and viral myocarditis group during recovery phase [ （89.75±9.90） μrno]/L] （P〈0. 01 ） . There was a significant negative correlation between nitric oxide and zinc in viral myocarditis group during acute phase （ P 〈0. 05 ） . Conclusion： The changes of serum nitric oxide and zinc levels are correlated with the occurrence and development of viral myoearditis.

关 键 词：病毒性心肌炎 一氧化氮 微量元素锌 

分 类 号：R725.4[医药卫生—儿科]