芘在Pluronic两亲嵌段共聚物胶团中的增溶  

Pyrene Solubilization in Aqueous Micellar Solutions of Pluronic Block Copolymers

作　　者：赵剑曦[1] 江琳沁[1] 陈颖[1] 戴闽光[1] 

机构地区：[1]福州大学化学系,中心实验室福州350002

出　　处：《Chinese Journal of Chemical Physics》2000年第1期123-128,共6页化学物理学报（英文）

基　　金：福建省自然科学基金;福建省高校科技项目;国家教委留学回国人员科研启动基金

摘　　要：用稳态荧光法研究芘（Ｐｙ）在Ｐｌｕｒｏｎｉｃ两亲嵌段共聚物胶团水溶液中的增溶，结果表明共聚物分子中的ＰＰＯ实际含量越大，越有利于Ｐｙ的增溶。加入无机盐ＫＣｌ导致生成了表面较少水化的较大胶团，并且由于ＫＣｌ解离产生的离子使溶剂极性增加，这些因素促进了Ｐｙ的增溶。Micelles of Pluronic block copolymers have recently displayed a potential application as drug microcarriers. In the application, one of the key problems is effective solubilization of hydrophobic drugs in the micelles. However, solubilization regularities of hydrophobic materials in Pluronic micelles have not been fully studied. In this paper, the solubilization of pyrene (Py) in the aqueous micellar solutions of Pluronic block copolymers has been investigated by steady-state fluorescent spectra. The results showed that the PPO content in Pluronic molecule is a key factor to determine Py amount adsorbed in the micelles. The greater is the PPO content, the much favorably solubilizate Py in the micelles.In the molecules of Pluronic copolymers studied in this paper, PPO content orders as F108(2920)> P85(2300)>F68 (1680) and thus the partition coefficients (Kv) of Py between the micelles and water are 8.3 x 10～4(F108, 35℃), 5.7 ×10~4 (P85, 35℃) and 2.2×103 (F68, 40℃), respectively. Addition of KCl leads to formation of the larger micelle with less hydrated shell. This means formation of a larger micellar core available to accommodating hydrophobic Py molecules, which is in agreement with the experimental results that showed an enhancement in Py solubilization as addition of KCl.

关 键 词：PLURONIC 嵌段共聚物 胶团增溶 芘 稳态荧光法 

分 类 号：O648.1[理学—物理化学]