化合物2-甲酰氨基噻唑-4-基乙酸的合成  

作　　者：孙伟东[1] 周淑华[1] 

机构地区：[1]哈药集团制药总厂,黑龙江哈尔滨150086

出　　处：《黑龙江科技信息》2012年第6期41-41,共1页Heilongjiang Science and Technology Information

摘　　要：目的:合成高纯度2-甲酰氨基噻唑-4-基乙酸。方法:以2-氨基噻唑-4-基乙酸乙酯、醋酸酐为起始原料,在甲酸作用下2位氨基经取代得到2-甲酰氨基噻唑-4-基乙酸乙酯,在经水解反应制得目标化合物,然后进一步精制纯化提高高纯度的目标化合物。结果:合成目标化合物的总收率为64.6%,纯度(HPLC)≥99%。结论:该法工艺简洁且原料价廉,设备要求不高,适合工业化生产。Objective：Synthesize high purity 2-formammidotiezol-4- acetoxy. Methods： use 2-aminothiazole-4 acetidin, acetic anhydride as the starting materials. Under the action of the methanoic acid, the 2 amino was substituted with 2-formammidotiezol-4-acetidin and then to get the final product through a lyric response,purify it further. Result： the total yield of the final product is 64.6% ,Purity （HPLC）≥99%. Conclusion： This technology suit for industrialization as it is concise, and the requirement of equipment for the technology is not high.

关 键 词：头孢替安 2-甲酰氨基噻唑-4-基乙酸 合成 纯度 

分 类 号：TQ252.5[化学工程—有机化工]